GHS Classification Result

Chemical Name：Lindane
CAS：58-89-9

Result：
ID: 612
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (1994))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1994) and stable to air (JMPR, 1968-2)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (1994))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Corrosive to metals (HSDB, Access on Jan. 2006)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The calculation was done based on rat LD50 values: 88mg/kg (ACGIH 7th, 2001, DFGOT vol.16, 2001, PATTY 4th, 1994), 200mg/kg (ACGIH 7th, 2001), 90mg/kg (PATTY 4th, 1994), 225mg/kg (DFGOT vol.16, 2001), 170 to 300 mg/kg (DFGOT vol.16, 2001), 125 to 230 mg/kg (IARC 20, 1979), 125mg/kg (PATTY 4th, 1994), and 90 to 270 mg/kg (EHC 124, 1991). The calculated value was 125mg/kg, and it was set as Category 3.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The calculation value rat LD50 = 450.9mg/kg : based on LD50 = 500 - 1000mg/kg (ACGIH 7th, 2001), 50 - 400mg/kg (DFGOT vol.16, 2001), 900 - 1000mg/kg (IARC 20, 1979), and 900mg/kg (EHC 124, 1991). And the calculation value rabbit LD50 = 68.5mg/kg : based on LD50 = 300mg/kg (ACGIH 7th, 2001, DFGOT vol.16, 2001), 75mg/kg (DFGOT vol.16, 2001), and 50mg/kg (DFGOT vol.16, 2001). The lower rabbit value was adopted, and it was set as Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Category 4 because of "SPECIES: Rat; ENDPOINT: LC50(4hr.; VALUE: 1.6mg/L"(DFGOT vol.16, 2001; EHC 124, 1991)
2 Skin corrosion/irritation Not classified - - - - From descriptions that irritation was not observed in the skin irritation test on rabbits (DFGOT (16 vol. 2001) and EHC 124 (1991)), it was classified as out of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It was set as Category 2B from description that mild irritation was admitted in the test applied to the eye of the rabbit of DFGOT (vol.16, 2001) and EHC 124 (1991).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - From the description that in a maximization test using the guinea pigs of DFGOT (vol.16, 2001) and EHC 124 (1991), the sensitization was not identified, it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - It gave a negative result in the dominant lethality test using the rat and mouse, which was the in vivo over generation mutagenicity test using the germ cells (DFGOT vol.16, 2001, EHC 124, 1991), and it gave negative in the chromosomal aberration test using the rat, mouse, or hamster marrow cells, which were the in vivo mutagenicity tests using the somatic cells, and it gave the negative result (DFGOT vol.16, 2001, EHC 124, 1991) in the micronucleus test which used the rat, mouse or hamster red corpuscles. So we classified it as Out Of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into group 2B by IARC(IARC Suppl.7, 1987), into 2B according to Japan Society for Occupational Health (Occupational Health Society advice, 2005), into A3 according to ACGIH (ACGIH 7th, 2001) and into R according to NTP (NTP RoC 11th, 2005). So it was set as category 2.
7 Reproductive toxicity Not classified - - - - Since there is no obvious reproductive toxicity at the dose causing general toxicity to parent animals in the oral administration reproduction study using rat and in the oral administration during pregnancy using rat, mouse, hare, or dog, (DFGOT (16 vol. 2001), IARC 20 (1979), PATTY (4th, 1994), and EHC 124 (1991)), it is considered as on the outside of Categry
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		According to the descriptions that influence on the nerve systems such as spasm etc., was identified in the human evidence of exposure (ACGIH (7th, 2001), DFGOT (16 vol. 2001), IARC 20 (1979), PATTY (4th, 1994), EHC 124 (1991)), and that by a transdermal medication test using rabbits, inhalation exposure test using the rat and oral medication test using dogs, influences on the nerve systems such as spasm etc. were identifitd with the dosage of the guidance value range of Category 1 (DFGOT (vol.16, 2001), EHC 124 (1991)). So it was set as Category 1(nerve systems).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney), Category 2 (testis) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney)
H373: May cause damage to organs through prolonged or repeated exposure (testis) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 1 (liver, kidney) and Category 2 (teste) according to the description that the effects on the liver and kidney were acknowledged by the dosage of the guidance value range of Category 1in the oral study using rats of DFGOT (vol.16, 2001), IRIS (2006), and EHC 124 (1991), and the description that the effects on the testes were acknowledged by the dosage of the guidance value range of Category 2 in the oral study using rats of EHC 124 (1991).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.00017mg/L of Crustacea (Pink shrimp) (EHC124, 1991) .
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=893 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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