GHS Classification Result

Chemical Name：heptachlor
CAS：76-44-8

Result：
ID: 615
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (1998))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1998)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (1998))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is information that it corrodes metal (HSDB (Access on Jan. 2006)), test methods suitable for a solids material are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Calculated based on rat LD50 values: 40mg/kg (MOE Risk Assessment the 1st volume, 2002, PATTY 4th, 1994, EHC 38, 1984), 90mg/kg (PATTY 4th, 1994), 100mg/kg (EHC 38, 1984, IARC 79, 2001, ATSDR, 2005), 80 to 90 mg/kg (EHC 38, 1984), 230mg/kg (ATSDR, 2005), 105mg/kg (ATSDR, 2005), and 71mg/kg (ATSDR, 2005). Since the calculated values was 59.7mg/kg, it was set as Category 3.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on the lowest value of a rat. (Rat LD50 values: 195mg/kg (PATTY 4th, 1994, EHC 38, 1984, ATSDR, 2005) and 119mg/kg (EHC 38, 1984), and rabbit LD50 values: 2000mg/kg (PATTY 4th, 1994) and 780mg/kg (PATTY 4th, 1994.))
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Based on description that in the rabbit skin application test both original product and 20% phthalates methyl solution show no skin irritation (PATTY (4th, 1994)), it was classified as the outside of Category.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - We found the negative results (IARC 79 (2001) ACGIH (7th, 2001) and ATSDR (2005)) for the dominant lethality tests using the rodents, which were the in vivo over generation mutagenicity tests using the germ cells, and found no positive results by the in vivo mutagenicity test using the germ cells and by the in vivo mutagenicity test using the somatic cells. Therefore we classified it as Out Of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into group 2B by IARC (IARC 79, 2001), into A3 by ACGIH A3 (ACGIH 7th, 2001), into B2 according to EPA in 1993 (IRIS, 2006), into category 3 by EU (EU-Annex I, 2006), and into 2B by Japan Society for Occupational Health (Occupational Health Society advice, 2005). So it was set as category 2.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is no description about the general toxicity to parent animals. Since there are descriptions that increased mortality of offspring and increased number of resorptions embryo were observed in the oral administration fertility study and the oral administration study in pregnancy on rat and mouse (ACGIH (7th, 2001), EHC 38 (1984), IARC 79 (2001), ATSDR (2005), and PATTY (4th, 1994)), and there is a description that the increased mortality rate in the offspring was observed in the rat oral administration study (ATSDR (2005)) at dosage even with the parents without specific toxicity dose, it was classified into Category 1B.
8 Specific target organ toxicity - Single exposure Category 1 (liver, nervous system) Danger H370: Causes damage to organs (liver, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the descriptions that in the oral medication test using rats a rise of irritability, shivering and the spasm were identified with the given dose of guidance value range of Category 1(PATTY (4th, 1994) and ATSDR (2005)), and that the unicellular necrosis of liver and air vessel-ization of hepatic cells were identified with the given dose of guidance value range of Category 1 in the oral midication test using rats (ATSDR (2005)),.it was set as Category 1 (liver, nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 1 (liver, nervous systems, kidney) according to the description that the effects on liver as fatty degeneration and hypertrophy of hepatocyte etc. was acknowledged with the given dose of the guidance value range of Category 1 in the oral study using rats, mice, or dogs of MOE Risk Assessment the 1st volume (2002), ACGIH (7th, 2001), ATSDR (2005), EHC 38 (1984), and PATTY (4th, 1994), and the description that convulsion and moderate fatty infiltration of the epithelium of the renal tubules in the oral study using rats of ACGIH (7th, 2001) and EHC 38 (1984) were acknowledged with the given dose of the guidance value range of Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.03microg/L of Crustacea (Pink shrimp) (MOE Risk Assessment No.1, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=17300 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information