GHS Classification Result

Chemical Name：Methomyl
CAS：16752-77-5

Result：
ID: 620
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid or solid substances at 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		SPECIES: Rat (male) ENDPOINT: LD50 VALUE: 51 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on rat (female) LD50 value: 1050mg/kg (Agricultural Chemicals abstracts).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on 25% wettable powder rat (male) LC50 (1 hour) value: 1.99mg/L (4-hour equivalent 0.498mg/L), and 35.56% liquid medicine rat (female) LC50 (1 hour) value: 0.61mg/L (4-hour equivalent 0.15mg/L) (all are agricultural-chemicals abstracts), the lower value was adopted and it was set as Category 2.
2 Skin corrosion/irritation Not classified - - - - Since it was judged to have no stimulativeness in the skin irritation test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Since change of the eye which was adapted to criteria for assessments of irritation in eye irritation tests using rabbits was not admitted (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since the rate of a positivity in the Buehler method test using the guinea pigs was 0% (Agricultural Chemicals abstracts), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Since we found the negative results by the micronucleus examination which used the mouse marrow cells, and by the chromosomal aberration test which used the rat marrow cells, which were the in vivo mutagenicity tests using the somatic cells (Agrichemical Abstracts), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into A4 (ACGIH 7th, 2001) according to ACGIH, it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - Since there is no reproductive toxicity in the dose causing general toxicity to parent animals in teratogenicity test of rat and rabbit, and in the reproduction study on rat (Agricultural-Chemicals abstracts), it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the oral administration and inhalation exposure tests using rats, symptoms suggesting the influences on the nerve systems such as clonic convulsion, shivering, salivation etc. were observed with the given dosage of guidance value range of Category 1 (Agricultural chemical abstracts). So it was set as Category1 (nerve systems).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as category 2 (nervous systems, blood) according to the symptoms which shows the effects on nervous systems such as decreased brain cholinesterase activity, tremor, aggressive behavior, and hyperreactivity, and the effects on blood systems such as decreased haemoglobin, reduction of red cell count, increased reticulocyte counts, and erythroid hyperplasia in marrow in the repeated oral test using rats were acknowledged with the given dose of the guidance value range of Category 2 (all by agricultural-chemicals abstracts).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=0.009mg/L of Crustacea (Daphnia magna) (EHC64, 1996) .
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=0.6(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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