GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：iodine
CAS：7553-56-2
Result：
| ID: | 623 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-combustible (ICSC (J) (2004)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible (ICSC (J), 2004) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (ICSC(J) (2004)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available by regulated examination methods, though it is a straong oxidizing agent (ICSC(J), 2004) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | SPECIES: Rat ENDPOINT: LD50 VALUE: 14000 mg/kg REFERENCE SOURCE: PATTY (4th, 1994), |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | There is a data with rat LCLo (1 hour) value: 0.8mg/L (4-hour equivalent 0.2 mg/L) (PATTY (4th, 1994)). But there is no data about LC50 value, and Category could not be specified. Therefore, it cannot be classifed since data is insufficient. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
There was no concrete case report. But from description that the skin water vacuole caused as a local effects (industrial hygiene society advice (1993)), it was judged to have skin irritativeness and it was classified as Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
There was no concrete case report. But from description that conjunctivitis was caused as a local effect on Occupational Health Recommendation of Occupational Exposure Limits (1993), it was judged that it was eye irritation. So it was set as Category 2A-2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
It is listed as the derma sensitization substance by the Japanese Society for Contact Dermatitis. Since it is listed in the 2nd skin group of the sensitization substance of The Japanese Industrial Hygene Academic Society's recommendation for acceptable density limit and as a skin sensitization substance by the Japanese Occupationl and Environmental Allergy Society, and case reports on separate contact dermatitis are found in the Japanese occupation and environmental allergology meeting's magazine 2004, ACGIH (7th, 2001) and PATTY (4th, 1994), it was referred to as Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Since we only found data of an in vitro examination (the gene mutation examination using the cultured mammalian cells: negative), we could not classify it. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 3 (respiratory irritant). Based on the description that airway irritation is identified in the inhaled steam and mist of the solution by humans (ACGIH (7th, 2001), PATTY (4th, 1994) and Japan Societ for Occupational Health Recommendation of Occupational Exposure Limits(1993)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (thyroid) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (thyroid) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified to as Category 1 (thyroid) from the description that the thyroid desease (hypothyroidism, hyperfunction, or thyroiditis) is caused by oral ingestion in humans of ATSDR (2004). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48-hour LC50=0.16mg/L of Crustacea (Daphnia magna) (ECETOC TR91, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are unknown. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |