GHS Classification Result

Chemical Name：Sulfuric acid
CAS：7664-93-9

Result：
ID: 626
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (ICSC(J), 2000; etc.).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC (J), 2000; etc.)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC (J), 2000; etc.)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 8
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although it is classified into the class 8 in UNRTDG, identification with skin corrosivity cannot be performed. Moreover, although there is also information that it corrodes almost all metals (ICSC (J) (2000)), there is no data based on set test methods.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rat LD50 value: 2140mg/kg (SIDS, 2001) and description that there is a report of deaths by the ingested doses (amount of ingested doses is unknown) in humans.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 value (4 hour exposure): 0.375mg/L (1-hour exposure) and : 347ppm (4 hour equivalent: 0.347mg/L) (all are (SIDS and 2001)), it was set as Category 2
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since pH of concentrated sulfuric acid was 1 or less, it was judged to be a corrosive substances with the GHS classification standards, and classified as Category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		From description that the critical damage to the eye accompanied by solutions of anterior chamber of eye was acknowledged in example of accident in human (ATSDR, 1998), and from description that moderate irritation with 5% liquid and severe irritation with 10% liquid were acknowledged to the eye of a rabbit (SIDS, 2001), and since pH of this product was two or less. So it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - There is no test data on skin sensitizing of sulfuric acids. Although sulfuric acid has been industrially used for several decades, there is no case report of skin sensitization, while skin injuries by skin irritation is well known. Although an extensive amount of sulfate ion exists internally (the sulfate ion in serum being 33 mmol/L and 50 times that in cells), allergic reactions do not occur. In metal study of allergic aspermatogenic sulfate, even if allergy positive with metal may occur, sulfuric ion is presumed to result in allegic negative as is suggested by the negative results in sulffate of zinc. Based on the description that a conclusion is drawn from the results mentioned above that sulfate does not cause allergy to humans(SIDS, 1998).Therefore it was put outside of the Category.
5 Germ cell mutagenicity Classification not possible - - - - For in vivo, any test data could not be found for which the productive cells and the somatic cells were used, and for in vitro mutagenicity tests, we found the positive result only in the test system with the single indicator (chromosomal aberration test) (ATSDR, 1998).And we found the negative results in other indices. Therefore we presupposed that we could not classify it.
6 Carcinogenicity Classification not possible - - - - Professional exposure of the mist of the inorganic strong acid including sulfuric acids is classified into group 1 according to IARC (1992), into A2 according to ACGIH (2004), and into K according to NTP (2005). And respecting evaluation of IARC and evaluation of the latest NTP, it is classified into category 1. However, sulfuric acids itself was classified into the category 4 according to DFGOT (vol.15, 2001). Also, none of those institutions has not carried out the carcinogenic classification, it was presupposed that it cannot be classifed.
7 Reproductive toxicity Not classified - - - - Since it is not observed of fetotoxicity and teratogenicity at the dose causing no maternal toxicity in inhalation test fetal period organogenesis rabbit and mouse (SIDS, 2001) and it was judged of no concern of reproductive toxicity because in chronic toxicity study and carcinogenicity tests, the effects on the reproductive organ of both sexes is not observed and the effect by irritation/caustic is main toxicity directly (SIDS, 2001), it wase considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the descriptions that in the inhalation exposure of low concentration by humans, airway irritation such as cough and breath shortness is identified (DFGOT, 2001), and at high exposure levels, acute effects such as cough, breath shortness and hemoptysis shedding etc., and permanent effects such as functional depression of lungs, fibrosis and emphysema were identified (ATSDR, 1998), and that hemorrhage in lungs and dysfunction were identified by 8-hour inhalation exposure in guinea pigs (ATSDR, 1998). So it was referred to as Category 1 (respiratory systems).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 28-day inhalation exposure test using rat , cell proliferation in laryngeal mucosa is acknowledged in guidance value of Category 1(SIDS (2001)), and in the 14 to 139-day repetition inhalation exposure test using the guinea pigs of the concentration of guidance value within the limits of Category 1, respiratory and lung disorder, such as nasal-septum dropsy, pulmonary emphysema, atelectasis, hyperemia, dropsy, bleeding and thrombosis of bronchioles are recognized (ATSDR(1998)), and further in the 78-week inhalation exposure test using a cynomolgus, histological change as hyperplasia of a cell, the wall thickening, etc. in bronchioles of lungs was acknowledged in the dosage (0.048 mg/L, 23.5 Hr/Day) of the range of the guidance value of Category 1, so it was classified to as Category 1 (respiratory systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour LC50=16-28mg/L of fishes (Bluegill) (SIDS, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Toxicity factor is considered to be strong acid as aqueous solution, but toxic effect is eased by the buffer action in the environmental water.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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