GHS Classification Result

Chemical Name:Adipic acid
CAS:124-04-9

Result:
ID: 632
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 420-422degC (Sax, 11th, 2004; ICSC(J), 1998; Chapman, 1982-2005)
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: > 11000 mg/kg REFERENCE SOURCE: PATTY (5th, 2001)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Since Saturated vapor pressure pressures concentrations is = 9.9ppm, it is thought that the inhalation study was done in mist. It was set as Category 5 based on rat LC50 = 7.7mg/L (CERI Hazard Data (1998)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on descriptions that the test on rabbits indicated mild irritation (CERI Hazard Data(1998), BUA 68 (1991)), and that it may dry skin and cause dermatitis on humans (ACGIH (2001)), it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the statement which moderate to severe irritation was indicated by the test using a rabbit (CERI Hazard Data (1998), PATTY (5th, 2001)), it was set as Category 2A. There is the preexisting classification of EU-Annex1: Xi; R36.
4 Respiratory sensitization Classification not possible - - - - Although there was a statement saying, "two workers handling adipic acid started bronchial asthmas" (CERI Hazard Data (1998), PATTY (5th, 2001), ACGIH (2001)), since none of the evaluation documents concluded that they were positivitie, it was decided that it could not be classified due to lack of sufficient data.
4 Skin sensitization Not classified - - - - Based on the statement of showing no skin sensitization in the test using the guinea pigs(CERI Hazard Data (1998), PATTY (5th, 2001)), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - We found the negative result for in vivo over generation mutagenicity test (dominant lethality test using the rat), and negative result for the in vivo mutagenicity test (chromosomal aberration test using rat myeloid cells) using the somatic cells (both in the CERI Hazard Data (1998) and BUA 68 (1991)). Therefore we classified it as Out Of Category according to the technical guideline.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - Since although there were many reports of no observing teratogenicity (ACGIH (2001), PATTY (5th, 2001), BUA 68 (1991), IUCLID (2000)), thre were no data of affecting reproduction function and potential to parent animals in premating administration, it was presupposed that it cannot classify.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the statement indicating that dust etc., may cause mild irritation to the mucous membrane of upper airway in humans. (CERI Hazard Data (1998), ACGIH (2001)), it was set as Category 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 1(Dust inhalation: autonomic nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (Dust inhalation: autonomic nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on description that ataxia of autonomic nervous systems and digestive organs was caused by occupational dust inhalation exposure in humans (CERI Hazard Data (1998), ACGIH (2001) and PATTY (5th, 2001)), it was classified to as Category 1 (autonomic nervous systems) (in the case of dust inhalation). In addition, there is a statement that harmful effect was not seen in the study of 1% feeding adminiswtration test (equivalent to 500 mg/kg/day) using the rat during 24 months (CERI Hazard Data (1998), ACGIH (2001) and PATTY (5th, 2001)) , and this dose exceeds the upper limit of the Category 2 guidance value range. Moreover, there is the description of having no toxic influence, even if humans eat it 100mg/kg/day(PATTY (5th, 2001)). In the case of oral, according to these things, it corresponds out of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 48-hour EC50=46mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1997).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since rapidly degrading (BOD: 81% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.08 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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