Chemical Name:Aspirin
CAS:50-78-2
ID: | 633 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Not ignite spontaneously on coming into contact with air at normal temperatures |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not classified | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements). |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Melting point: >55degC and solid. Test methods are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
SPECIES: Rat; ENDPOINT: LD50; VALUE: about 1500mg/kg; REFERENCE SOURCE: IUCLID (2000) | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | There are findings in animal studies that irritation is mild (IUCLID (20000)), ut that there is irritation on humans (ACGIH (2001), ICSC (J) (1998)). |
3 | Serious eye damage/eye irritation | Category 2A | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
There is moderate irritation with a rabbit (IUCLID (2000)). | |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
There is knowledge of respiratory sensitization (ACGIH (2001), IUCLID (2000)). | |
4 | Skin sensitization | Classification not possible | - | - | - | - | As there is no data on the skin sensitization, it cannot be classified.. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | We found no information on the mammals in vivo genotoxicity study, and we found the negative results for almost all the in vitro mutagenicity tests (IUCLID (2000)). |
6 | Carcinogenicity | Not classified | - | - | - | - | Although there is no classification by an evaluation organization, anticancer effects is seen by the animal studies (IUCLID (2000)). It is used as an anticancer drugs (PATTY (5th, 2001)). |
7 | Reproductive toxicity | Category 1A | Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is a report which indicates reproductive toxicity on humans. (RTECS(2005)) | |
8 | Specific target organ toxicity - Single exposure | Category 2 (lung, kidney, stomach) | Warning | H371: May cause damage to organs (lung, kidney, stomach) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Since a description stating that effects were observed in human lung, kidney and stomach is found in (RTECS (2005)) of Priority 2, it was set as Category 2. | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, auditory organ, blood system, central nervous system) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver, auditory organ, blood system, central nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Although effects on liver, hearing, blood systems and a central nervous system are seen in humans(RETCS (2005)), it was classified to as Category 2 because of the literature of Prioty 2. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified | - | - | - | - | It carried out the outside of Category from 48-hour EC50>100mg/L of Crustacea (Daphnia magna) (IUCLID, 2000). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since not water-insoluble (aqueous solubility =4600 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website (in Japanese Only) |