GHS Classification Result

Chemical Name：Acetophenone
CAS：98-86-2

Result：
ID: 634
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Although flash point data varies from 82 - 105 degC, it was classified as Category 4 (GHS standards: flash point being more than 60 degC but 93 degC or less) as the lowest flash point being 82 degC (Open Cup).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 570 - 571 degC (Chapman (1982-200), an organic compounds dictionary (1985), ICSC (J), (1994))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on rat LD50=956.3 mg/kg calculated from four test results (900, 900, 3000, and 3200 mg/kg) (PATTY (5th, 2001)) of rat LD50.
1 Acute toxicity （Dermal） Not classified - - - - Based on guinea pig LD50 >20600mg/kg (PATTY (5th, 2001)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - The saturated vapor pressure concentration of acetophenones is 523.7ppm (25degC). And it was presumed that the inhalation test was done in the state of steam. But LC50 value was unknown (PATTY (5th, 2001)), it was presupposed that it cannot be classified due to data insufficiency.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - The saturated vapor pressures concentrations pressure of acetophenones is 523.7ppm (25degC), it is presumed that the inhalation study was done in the state of steam. There is no data about mists.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the descriptions of slight edema (IUCLID (2000)) and mild skin reaction (RTECS (2005)) in rabbit tests, it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the statement of severe irritation (PATTY (5th, 2001)) and moderate irritation, and transient cornea damage (IUCLID (2000)) by the test using a rabbit, it was set as Category 2A. In addition, there is the preexisting classification of EU-Annex 1: Xi; R36.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the negative statement of the test cases in humans and guinea pigs(PATTY (5th, 2001)) , it was put outside of the Category.
5 Germ cell mutagenicity Classification not possible - - - - Since we only found the data of the in vitro mutagenicity test and found no strong positive findings, we presupposed that we could not categorze it by the technical guideline.
6 Carcinogenicity Not classified - - - - Based on the technical guide, it considered as the outside of Category from the segment D of EPA (IRIS (2004)).
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the descriptions that there are cases that it was used as an anesthetics by humans (ACGIH (2001)), and that anesthetic actions were observed by medication to rats (PATTY (5th, 2001)), it was set as Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - It is indicated that harmful effects were not seen in the 10000 ppm feeding administration test for 17 weeks using a rat (equivalent to about 500 mg/kg/day by a technical guide) (PATTY (5th, 2001) and ACGIH (2001)) and this dose exceeds the upper limit of the Category 2 guidance value range. Moreover, also in occupational exposure in humans, there is the statement that harmful effect is not reported (ACGIH (2001)). It was classified to outside of Category according to these things.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50=162mg/L of fishes (Fathead minnows) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility = 6130 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information