GHS Classification Result

Chemical Name：Metribuzin
CAS：21087-64-9

Result：
ID: 637
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature (Dictionary of Organic Compounds, 1985)
11 Self-heating substances and mixtures Classification not possible - - - - The melting points is 140 degC or less (melting points: 126 degC, organic compounds dictionary (1985)), and cannot apply the examining method.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Since rat female LD50 value was 2020mg/kg (Agricultural-Chemicals abstracts), it was set as Category 5.
1 Acute toxicity （Dermal） Not classified - - - - Since death was not observed at 2000mg/kg in the rat dermal toxicity studies (Agricultural-Chemicals abstracts), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - It is female rats LC50 >0.86mg/L (Agricultural-Chemicals abstracts), and cannot be classified.
2 Skin corrosion/irritation Not classified - - - - Irritation was not observed at all in rabbit skin irritation test (Agricultural-Chemicals abstracts). Therefore, it was classified as out of Category. In addition, it is also reported to have no irritativeness on human skin (HSDB, 2005).
3 Serious eye damage/eye irritation Not classified - - - - Based on that irritation against ocular-mucous and response to corneal were not produced in eye irritation tests with rabbits (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the fact that sensitization was not identified in the FDA test(Agricultural chemicals abstract) using the guinea pigs, it was put outside of the Category. In addition, it has been reported that there is no skin sensitization in humans either. (HSDB (2005)).
5 Germ cell mutagenicity Not classified - - - - It gave negative by the micronucleus test (in vivo) which used bone marrow cells of the mouse, and by the genotoxic tests (in vivo) which used the germ cells of the Chinese hamster (Agricultural-Chemicals Abstracts). Therefore we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - It was carried out the outside of category based on that the existing segment is D in EPA and A4 in ACGIH. In addition, carcinogenicity is not acknowledged in carcinogenicity tests of mouse (Agricultural-Chemicals abstracts).
7 Reproductive toxicity Not classified - - - - Since there was no effects on the reproductive potential in the rat two-generation reproductive toxicity test (GLP) and it was not observed of developmental toxicity in rat and rabbit teratogenicity test (GLP) (Agricultural-Chemicals abstracts), it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Not classified - - - - Since only slight influences are reported with regard to the oral administration, transdermal intake or inhalation by rats (Agricultural chemical abstracts), it was put outside of the Category.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Although change in organ weight is reported in the 90-days oral administration test using rats, other critical adverse effect is not observed in the dosage of 105mg/kg which is beyond the maximum (100mg/(kg)) of the guidance value of Category 2 (Agricultural Chemicals abstracts). Therefore, it was classified to as the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from ErC50=29.4microg/L of the algae (Green algae) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.7 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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