GHS Classification Result

Chemical Name：2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
CAS：1918-02-1

Result：
ID: 638
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification not possible due to lask of data, though "Flammable" (BGIA, GESTIS-database on hazardous substancess, Accessed in 2006)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although HSDB (2005) has the description "caustic is slightly indicated only in mild steel", test methods suitable for a solids material are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. The higher one of toxicity (LD50=4012 mg/kg) was adopted among rat oral LD50s= 8.2 g/kg (ACGIH (7th, 2001)) and 4012 mg/kg (RTECS (2004)), and it was set as Category 5.
1 Acute toxicity （Dermal） Classification not possible - - - - IARC 53 (1991) describes rabbit dermal LD50 is >4000 mg/kg bw. Although it corresponded to Category 5 or outside of Category, the status of deaths was not able to be checked. So it could not be classified.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since there were descriptions of mild irritant on human skin (ICSC (J) (1995), HSDB (2005), HSFS (2001), SITTIG (4th, 2002)), it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since there was description that the human eye was stimulated (ICSC (J), (1995), HSDB (2005), HSFS (2001), SITTIG (4th, 2002)), it was set as Category 2A-2B. [view] It is more desirable to make it Category 2A from a viewpoint of safety, when subdivision needs to be performed.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since there is a description in the document of Priority 1 "an evidence that indicates skin sensitization was not identified after giving medication to human subjects " (ACGIH (7th, 2001)), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Since there were negative reports by the chromosomal aberration test using the marrow cells of the mouse and the rat (IARC 53 (1991), HSDB (2005)), we classified it as Out Of Category. In addition, it gave negative also for the Ames test (in vitro mutagenicity test), the chromosomal aberration test, and for the cultured cell gene mutation examination (ACGIH (2001), IARC 53 (1991), HSDB (2005)).
6 Carcinogenicity Not classified - - - - Since it was categoried according to IARC with 3 (IARC 53 (1991)) and was categoried according to ACGIH with A4 (ACGIH (7th, 2001)), it carried out the outside of Category by the guideline.
7 Reproductive toxicity Not classified - - - - Since it is observed that testicular atrophy was occured in male rats administrated of this substance (NTP TR23 (1978)), but this has also occurred in non-administered groups, it is not indication of clear reproductive toxicity og this substances. Furthermore, there are findings of the growth retardation but not teratogenicity and no effects to survival or development of newborn indants in offsprings of test rats (ACGIH (7th, 2001) and IARC 53 (1991)). Based on the above mentioned, it was judged that there was no specific reproductive toxicity in this substance and it was placed out of classification.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was a description that the human airway is irritated by this substance (ICSC (J) (1995), HSDB (2005), SITTIG (4th, 2002)), it was set as Category 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In Priority 2, since there was description that human liver and kidneys are affected (ICSC (J), (1995), HSFS (2001), SITTIG (4th, 2002)), it was classified to as Category 2 (liver, kidney). In addition, many repetition toxicity studies (oral administration) using a rat or a mouse are performed and the effects on the liver and renal is indicated (ACGIH (7th, 2001), IRIS (1992), IARC 53 (1991), HSDB (2005)) but these dose in a guidance value is within the Category 2 or above .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.027mg/L of Crustacea (Amphipod) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=0.3(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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