GHS Classification Result

Chemical Name：Fenamiphos
CAS：22224-92-6

Result：
ID: 647
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It was judged that it did not ignite spontaneously even if it contacts air from the description "it burns but it does not ignite easily" (NAEGG (J), (2001)).
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Since it was described as "In laboratory conditions and fenamiphos is stable at pH 5-7" (HSDB (2005)), it was judged that it was stable to the water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For a classification, rat LD50 value (JMPR 929 (1997)) of eight pieces are corresponded. And it was set as Category 2 based on calculated values 5.23 mg/kg by statistical calculations.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For a classification, five rat LD50 value (JMPR 929 (1997), JMPR 300 (1974)) and two rabbit LD50 value (JMPR 929 (1997)) were corresponded. And 72mg/kg and 179mg/kg were obtained by statistical calculations, respectively. It was set as Category 2 based on 72mg/kg of the lower rat value.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of "SPECIES: Rat; ENDPOINT: LC50 ; VALUE: 0.091-0.10 mg/L (4 h)" (JMPR 929, 1997)
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From evaluation results of several rabbit skin irritation tests that "not a primary irritant" (JMPR 929 (1997)), "minimal irritation" (JMPR 929 (1997)) or "only slightly irritant" (PATTY (5th, 2001)), it was judged to have mild irritativeness and was classified as Category 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In the eye irritation test using a rabbit, range is seen in decision, including "mild irritation" (PATTY (5th, 2001)), "recovered within ten days in irritation of moderate" (JMPR 929 (1997)), "damage is not disappeared by 21days after eye drop" (ACGIH (2001)), and "physical irritation rather than physiological irritation". However, since the description about the eye on ICSC (1998) was not referred to stimulativeness only the contracted pupil by inhalation, it was hard to consider that it had irreversible stimulativeness at least, and it was judged as mild to moderate stimulativeness. So it was taken as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - It has been estimated in a skin sensitivity test using a guinea pigs(Maximization test) that erythema was identified in part but it was below the standard as a skin reactions and therefore no sensitization seems to exsist (JMPR 929 (1997).). Furthermore, since another information source states that no sensitization was identified(PATTY (5th, 2001), IUCLID (2000)), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Based on the negative results (JMPR 300 (1974), PATTY (5th, 2001)) of the dominant lethality tests (in vivo over generation mutagenicity test) using the mouse, we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Besed on what is classified into A4 according to ACGIH (1996), it carried out the outside of category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is not observed bad effect on reproductive potential and fetal development and teratogenicity in rat two-generation test or each administration test during premating to pregnant and lacting period or organogenetic period (PATTY (5th, 2001), JMPR 929 (1997)). However, since it is observed of skeletal malformation (sternal fusion) in rabbit organogenetic period administration test with dose causing general toxicity to maternal animals (ACGIH (2001), PATTY (5th, 2001)), it is classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Cholinergic symptoms such as contraction of muscles, spasm, impaired coordination, and laborious breathing have been reported by oral administration (dosage of a few mg/kg weight) to rats causing inhibition of the cholinesterase activities (JMPR 929 (1997)). It was set as Category 1(nervous systems) with reference to the guidance value. In addition, there is no direct information regarding humans and only report was the epidemiologic survey about organic phosphorus poisoning (HSDB (2005)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Cholinergic syndrome (spasm of a muscular etc.) is observed in a rat and a dog by dosage more than several mg/kg weight, and simultaneously the remarkable decrease of red corpuscle cholinesterase (about 50% of inhibition rate) is accepted (JMPR 929 (1997), PATTY (5th, 2001)). They are the symptoms caused by overstimulation of the nerve fiber receptor with cholinesterase inhibition that is characteristic of an organophosphorus agent, and it was classified to as Category 1 (nervous systems), considering a guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.01-0.017mg/L of fishes (Bluegill) (PDS, 1994).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.23(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

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