GHS Classification Result

Chemical Name：Propane, 2,2'-oxybis-
CAS：108-20-3

Result：
ID: 649
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 2 because of its flash point: -21.5 - -28degC, boiling point: 68.27 - 69degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 405-443degC (IUCLID , 2000; Chapman (CD-ROM Ver.13.1)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG Class: 3, PG II
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - From LD50 value in 5 oral administration examinations (ACGIH (2001), PATTY (5th, 2001)) of rats, it was set as the outside of Category. This is based on LD50=6033 mg/kg calculated by the process of technical guides.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 value = 20mL/kg (RTECS (2004), reduced value:14600mg/kg) and 20000mg/kg (IUCLID (2000)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - The saturated vapor pressure concentration of this product is 197000ppm. Each inhalation test is done by 90% or less of saturated vapor pressure concentration, it is thought that the test was done with vapor. Since the rat lethal concentration in 4-hour exposure is stated to be 1.6% (equivalent: 16000ppm) (PATTY (5th, 2001)), LC50 value was supposed to be more than 16000ppm, and it was classified as outside of Category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is a description that it caused dermatitis with repetitive administration for ten days, but it was reversible (ACGIH (2001), IUCLID (2000), HSDB (2003)), and there is description that dermal reaction of rabbits in Open irritation test was "mild" (RTECS (2004)). So it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the statement that irritation was acknowledged (IUCLID (2000)) and "minor injury"was produced (HSDB (2003)) in rabbit tests, and based on the statement that irritation was acknowledged in the eye by 800ppm and 5 min in humans, it was set as Category 2A-2B (ACGIH (2001)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - We found a negative result by the in vitro test (IUCLID (2000)), however, we found no in vivo data. Therefore we could not classify it for the insufficiency of data.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was description that no general toxicity effect on parental animals but it is observed effects on estrous cycle, pregnancy rate and conception rate in rat (RTECS (2004)), it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects) Warning H371: May cause damage to organs (central nervous system)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There is the description that the inhalation in high concentration to human may cause central nerve inhibition and deth by respiratory paralysis (HSDB (2003)), and it is classified into Category 2 (central nervous system). There is the description that it stimulates human nose and make it difficult to breathe (PATTY (5th, 2001), ACGIH (2001)), and the descriptiont about the anesthetic action in animals (PATTY (5th, 2001)). So it is classified into Category 3 (respiratory irritant, anesthetic action).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there is a statement that abnormalities were not acknowledged with the amount of exposure higher than the upper limit of the guidance value range of Category 2 in the 90-day exposure tests for 6 hours per day (HSDB (2003)), it was presupposed to be unclassifiable because of insufficient data of only one data in Priority 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour LC50=91.7mg/L of fishes (Fathead minnows) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (log Kow=1.52(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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