GHS Classification Result

Chemical Name：Flutolanil
CAS：66332-96-5

Result：
ID: 650
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since it is thermostable at 150 degC (Agricultural Chemical Registration Data (1996)), it is judged that it does not ignite spontaneously even if it contacts air.
11 Self-heating substances and mixtures Classification not possible - - - - The melting points is 140 degC or less, and the test suitable for a liquid state substance has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and fluorine (but not chlorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Melting point: >55degC

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - It was set as the outside of Category from rat LD50 > 10000mg/kg (Agricultural Chemical Registration Data (1996)).
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category from rat LD50 >5000mg/kg (Agricultural Chemical Registration Data (1996)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on rat LC50 >5.98mg/L (Agricultural Chemical Registration Data (1996)) and description of "having no example of death", it was set as the outside of Category.
2 Skin corrosion/irritation Not classified - - - - As it was judged to have almost no skin irritation in the skin irritation test on guinea pigs (Agricultural Chemical Registration Data (1996)), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Based on description (Agricultural Chemical Registration Data (1996)) "irritation was not indicated at all to the palpebral conjunctiva, the eyeball conjunctiva, and the cornea"as a result of the eye irritation examination using a rabbit, it was considered as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since skin reactions were not identified at all by the Magnusson-Kligman Maximisation method using a guinea pigs(Agricultural Chemical Registration Data (1996)), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Based on the negative result by the in vivo micronucleus examination (somatic cell in vivo mutagenicity test) using the mouse (Agricultural Chemical Registration Data (2005)), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - As a result of the examination by long-term mix feed medication using rats and mice, the increase in the tumorigenic frequency originated from medication is not admitted in both animal kinds (Agricultural Chemical Registration Data (1996)). And having been evaluated as "not carcinogenic" in the pesticide residues stability monitoring board, it carried out the outside of category.
7 Reproductive toxicity Not classified - - - - There is no effect to reproductive function and reproductive potential such as mating, delivery and nursing in the rat two generation reproduction study (Agricultural Chemical Registration Data (1996)), and there is no effect of considerable caused by test subject administration on the test of fetal external surface, organs and sccafold in the organogenetic period teratogenicity test to rat and rabbit (Agricultural Chemical Registration Data (1996)). As mentioned above, since it was judged having reproductive toxicity, it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Not classified - - - - There is the fact that there is the effect only to the fall of transient locomotor activity by the dose up to 10000mg/kg via the oral route, and there is no effect by test substance by the concentration of 5.98mg/L of inhalation, for both of male and female, in the single exposure test by oral or inhalations (dust) using a rat (Agricultural Chemical Registration Data (1996)). So it is classified as the out of the Category
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In the 13-week repetition oral administration examination using rats,mice or dogs, material toxic effect is not acknowledged by the dose exceeding a guidance value maximum (100 mg/kg/day) (Agricultural Chemical Registration Data (2005), JMPR (2002)). Moreover, also when it is administrated orally over a long-term (one-year and half-two years) to a rat, mice or dogs, the serious influence in the dosage exceeding a guidance value range maximum is not admitted (JMPR (2002)). Thus, in each test of defferent administration period using multiple species, all were carried out the outside of Category based on the fact of not admitting material toxic effect, by each dose exceeding a guidance value range maximum. In addition, the increase in weight of liver and the thyroid gland, and the fatty degeneration and vacuolation of hepatocyte, etc. are reported in the high capacity doses (Agricultural Chemical Registration Data (2005), JMPR (2002)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=3.21mg/L of fishes (Carp) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=3.7(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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