GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：3-Methylbutan-1-ol
CAS：123-51-3
Result：
| ID: | 651 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point: 23degC to 60degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | It is accepted that even if it contacts air in room temperatures, it does not igniting spontaneously, from the experience at the time of manufacture and dealings. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | No data available on corrosion to metals |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | The statistical work was done among five data (ACGIH (2001), IUCLID (2000), RTECS (2000)) excluding one data (Patty (5th.2001)) reported by range. And LD50: 2592mg/kg was obtained, it was set as Category 5. |
| 1 | Acute toxicity （Dermal） | Category 5 | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | It was set as Category 5 since there were data of rabbit LD50: 3250mg/kg (ACGIH (2001)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Mortality was not observed in 2000ppm and 8 hours (concentration equivalent to Category 4) (ACGIH 2001). Since there is no examination data with lethal concentration, it cannot be classified. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Although there is one positive case on human, no stimulating is reported in other reports (Patty (5th. 2001)). The stimulation on animal is also very slight (ACGIH (2001)). Based on these, it was classified as out of Category. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Since the strong stimulus was given to the eye of a rabbit (ACGIH (2001)), it was set as "Category 2A." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Sensitization reports of respiratory tracts are not found. |
| 4 | Skin sensitization | Not classified | - | - | - | - | Since there was no positive findings in the human skin and sensitizztion was not identified(IUCLID (2000)), the skin sensitization was put outside of the Category. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | There was no In vivo test reports and we judged that "we cannot classify it." For in vitro tests, one affair was positive among 3 reports (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Since the experimental result in rats is not considered as a decisive thing (ACGIH (2001)) and there is also no existing classification of an evaluation organization, it cannot be classified. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Data is insufficient and it cannot be classified. The bad effect within the dose not affecting maternal is not observed in the pregnant rabbit and rat administration test . (Patty 5th(2001)) |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (narcotic effects, respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (central nervous system) H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
There is the information about the inhalation in human (Nelson et al., Patty (5th.2001)), "Category 3" is used (respiratory irritation). Moreover, the effects of oral ingestion (Ardeev, Patty (5th.2001)) is central nervous system inhibition. Although it corresponded to "Category 3 (anesthesia)", there was also an example of fatality. So "Category 1" was taken. |
| 9 | Specific target organ toxicity - Repeated exposure | Not classified (oral) | - | - | - | - | Since the harmful effects were seen only with the hgih-capacity dose (oral of 1000mg/kg or more) than the oral guidance value (100mg/(kg)) , it carried out "Category Outside." |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Although dynamic viscosity applied to the definition of Category 2 and the similar substance was mentioned in the ICSC, we could not find the information on the aspiration hazardous property of this substance itself. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | It carried out the outside of Category from 48-hour EC50=260mg/L of Crustacea (Daphnia magna) (IUCLID, 2000). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since not water-insoluble (aqueous solubility =26700 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |