GHS Classification Result

Chemical Name:2-Cyclohexen-1-one, 3,5,5-trimethyl-
CAS:78-59-1

Result:
ID: 652
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification not possible due to lack of data, though the substance contains unsaturated C-C bonds as chemical groups associated with explosive properties present.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Although flash point by open cup measuring device was 96.1 degC, it adopted 84 degC of flash point by a closed cup flash point analyzer device, and was classified as Category 4 (GHS standards: flash point being more than 60 degC and 93 degC or less).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains unsaturated C-C bonds as chemical groups with self-reactive properties present.
9 Pyrophoric liquids Not classified - - - - The ignition points is 460 - 462 degC (ICSC (J) (2000), pocket book books (1997))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
It was set as Category 4 based on rat LD50 =1843mg/kg: calculated by the technical guideline using seven data of rat (SIDS (2003), EHC 174 (1995)).
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
LD50 = 1265mg/kg calculated by the technical guideline using 4 examination of rabbits (SIDS (2003), PATTY (5th, 2001)). And LD50 = 1700mg/kg (SIDS (2003)) of a rat examination. It was set as Category 4 based on the lower value.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. It done by higher concentrations than the saturated vapor pressure pressures concentrations, and based on LC50 = 7mg/L (SIDS (2003)) of the rat inhalation test considered to be mist tests. So it was set as Category 5
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the report that in test of less than 4 hours on rabbits or guinea pigs, there was mild skin irritation or no stimulativeness observed (SIDS (2003), EHC 174 (1995), PATTY (5th, 2001)), it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
There is the statement that humans had eye irritationt (ACGIH (2001), SIDS (2003)), and that there was moderate or mild eye irritation (SIDS(2003), EHC 174 (1995)), and that although moderate to severe impairment was produced, it recovered within 14 days in rabbit test (SIDS (2003)). So it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the statements that sensitization was not identified in guinea pigs tests [ SIDS (2003) and EHC 174 (1995)] and that there is no sensitization in humans(SIDS (2003), ECETOC JACC 10 (1989)), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - The lack of results for human over generation epidemiology, the over generation mutagenicity test, and the productive cell in vivo mutagenicity test, and based on the statement that it gave negative by two in vivo somatic mutagenicity examinations (mouse bone marrow cells micronucleus test) (SIDS (2003), EHC 174 (1995), ECETOC JACC 10 (1989)). So we classified it as Out Of Category by the technical guideline.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as 2. Based on being classified into A3 according to ACGIH (ACGIH (2001)), and being classified into a category 3 by EU and R40 being given (EU-Annex I (2005)).
7 Reproductive toxicity Not classified - - - - Since it is not observed that adverse effects on genital tract and fetal development in the rat or mouse test (SIDS (2003), EHC 174 (1995), PATTY (5th, 2001)) and the dog study (SIDS (2003)), it is considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is the respiratory irritation (irritation of nose and throat) and anesthetic action (nausea, headache, dizziness, faint, choking sensation) (ACGIH (2001), EHC 174 (1995)) in human exposure report. And there is the description that there is respiratory irritation also in rat and rabbit (EHC 174 (1995)) and there are symptoms which indicate anesthetic action such as ataxia, suppression state and coma (EHC 174 (1995), SIDS (2003)). So it is classified into Category 3 (respiratory irritation and anesthetic action)
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the example of exposure in the humans mentioned of SIDS (2003), effects to specific organ is not admitted, but only fatigue and malaise are reported. In an animal examination, serious effects on specific organ is not admitted by oral dosage higher than the guidance value of Category 2 (SIDS (2003), EHC 174 (1995)). However, the affect (bleeding,edema,inflammatory,changes in the tissue) on lungs and the affect (changes in the tissues) on the kidney are mentioned with higher dosage than the guidance value of 2 in the inhalation test of the animal (EHC 174 (1995), PATTY (5th, 2001)). In order that there might be no data which serves as a conclusive factor of a classification among the above informations, it was presupposed that it cannot be classified.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96-hour LC50=12.9mg/L of Crustacea (Mysid shrimp) (SIDS, 2005).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since rapidly degrading (28-day decomposition rate of the OECD test guideline 301A: 95% (SIDS, 2003)), and less bio-accumulative (BCF=1.8 (Existing Chemicals Safety Check Data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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