GHS Classification Result

Chemical Name：fonofos
CAS：944-22-9

Result：
ID: 668
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 4 because of its flash point: 90degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-reactive properties present.
9 Pyrophoric liquids Not classified - - - - Since measurements of flash points was made under temperatures higher than the room temperatures (94 degC) (ICSC (1997)), it was judged as not igniting spontaneously in normal temperatures, it was classified as outside of Category.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although the corrosion to steels is indicated (HSDB (2005)), since there are no other data, it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on LD50=5.74 mg/kg calculated by nine data (ACGIH (2001), PATTY (5th, 2001), PIMs (1998)) of rats. In addition, only one data of PATTY (5th, 2001) described LD50 with dividing into racemic mixtures, S object, and R object. But all other data had particularly made reference about used isomer, it considered altogether that it was racemic mixtures. And it used only the value of racemic mixtures for calculation also from one data of PATTY (5th, 2001).
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on LD50 = 147mg/kg (ACGIH (2001)) in rat dermal administration.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since the saturated vapor pressures concentrations pressure of this product is 0.49ppm, it is thought that the inhalation study was done in mist. Based on LC50 = 0.225mg/L (4-hour equivalent) which is the lower one among the rat inhalation 2 data (ACGIH (2001)), it was set as Category 2.
2 Skin corrosion/irritation Not classified - - - - Based on the statement that skin irritation was not indicated on rabbits (ACGIH (2001), PATTY (5th, 2001)), it was classified as out of Category.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is a statement that stimulation for the eyes of rabbits can be disregarded (ACGIH (2001), PATTY (5th, 2001)), and in humans, there are statements that an eye may be stimulated (ACGIH (2001)), and that when an eye are contacted, redness, a pain, and a blurred vision are produced (ICSC (1997)). It was set as Category 2A-2B based on the humans information.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - We found no human over generation epidemiology, the over generation mutagenicity test, and the productive cell in vivo mutagenicity test, in addition, it gave negative for somatic cell in vivo mutagenicity test (micronucleus test which used mouse bone marrow cells) (HSDB (2005)). Therefore we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into A4 according to ACGIH (ACGIH-TLV(2005) cited in HSDB (2005)), it carried out the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is also a statement that parents' reproductive potential and the offsprings' growth and development were not affected in three-generation tests of rats (ACGIH (2001), PATTY (5th, 2001)). Since there is a statement that in rabbit organogenetic-period administration tests, postimplantation death increased at a dose which is mildly toxic to maternal animals (HSDB (2005)), it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the findings that suggest the effect to nervous system such as muscle fiber spasm, thrill, salivation, panting in the dose in the guidance value range of Category 1 in rat (ACGIH (2001)). There is the examples of nervous system disorders such as malevolence/vomiting, salivation, diaphoresis, muscle fiber spasm, myosis, dizziness, bleary eyes from the ingestion of this substance in human, and there is the description that there is the appearance of these symptoms as nervous symptom by the inhibition of cholinesterase. It is classified into Category 1 (nervous systems) from the above thing.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver, small intestine) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, small intestine) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There is a statement that in rats and dogs, the cholinesterase inhibition in red blood cell and plasma or serum, and histologic changes of small intestine and liver are observed in the dosage of guidance value within the limits of category 1(PATTY (5th, 2001), HSDB (2005)). There is a statement that in humans cholinesterase inhibition, depression, anxiety, convulsion and respiratory insufficiency etc. owing to neuropathy and hepatic dysfunction may be occured (ICSC (J), (1997), HSFS (1999), SITTIG (2002)). It was classified to as Category 1 (a nervous system, liver, small intestine) based on the above informations.
10 Aspiration hazard Classification not possible - - - - Insufficient data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=1.09mg/L of fishes (Fathead minnows) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=3.94(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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