GHS Classification Result

Chemical Name：Ethanol, 2-(1-methylethoxy)-
CAS：109-59-1

Result：
ID: 672
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 3 because of its flash point: 33.3degC (Solvent Pocket Book, 1997)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Since the fire points is 240 degC (ICSC (J) (2004)) which exceed 70 degC, it was classified as the outside of Category.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Diluent type A >=55%, Available oxygen <=10%, UNRTDG No.3105, Class:5.2, GHS Classification, Organic peroxides type D
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Two sorts of LD50 values were indicated as a result of oral administration in rats. And the lower value of LD50=5600 mg/kg (ECETOC TR64 (1995)) was taken, it was set as the outside of Category.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was set as Category 4 from rabbit percutaneous LD50 = 1440mg/kg (1.6ml/kg) (DFGOT vol.V (1993)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was classified as Category 4 based on rat inhalation LC50 = 4000ppm (DFGOT vol.V (1993), ECETOC TR64 (1995)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Saturated concentration is 6961ppm and it is guessed that each inhalation study is performed in the state of steam. Since there is no data about mists, it cannot be classified.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Since it was classified as Moderate according to the Draize method (RTECS (2004)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It was set as Category 2B based on the statement of recovering within seven days although there was irritation (DFGOT vol.V (1993), ECETOC TR4 (1982), PATTY(5th, 2001) vol.7).
4 Respiratory sensitization Classification not possible - - - - Since there was no data, it was decided that it could not be classified.
4 Skin sensitization Not classified - - - - Based on the test report with guinea pigs that sensitization was not identified(PATTY(5th, 2001) vol.7), it was put outside of the Category.
5 Germ cell mutagenicity Classification not possible - - - - Since there was only in vitro data for mutagenicity test, we presupposed that we could not classify it according to the technical guideline.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Not classified - - - - Since it is not observed of changes, considered cause using 2-(1-methyl ethoxy) ethanol, of items as estrous cycle, pregnant period, delivery and nursing condition etc. in rat oral administration during premating to pregnant period (Ministry of Health and Welfare reports (2005)), it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (blood) Danger H370: Causes damage to organs (blood) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Addition to the blood (hemoglobinuria), central nervous system, liver, kidney, and spleen are mentioned as target organ. Among these, there is the report about the blood (much blood passed in urine), and the kidney (severely affected kidney) (PATTY (5th, 2001) vol.7). Although it is in the guidance value of Category 1, the kidney is considered as the secondary effects by hemolysis, it is classified into Category 1 (blood). Since dose is unknown and dose symptoms was weak about a central nervous system, liver and spleen, it was not able to classify.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 2 (blood), since within the limits of the guidance value of Category 2, an anemia by oral (Ministry of Health and Welfare reports (2005)) and hemolysis (hemoglobinuria) and anemia (DFGOT vol.V (1993)) by inhalation were reported.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 2001).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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