GHS Classification Result

Chemical Name:Ethanol, 2-butoxy-
CAS:111-76-2

Result:
ID: 673
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: 61-62degC (Merck 13th, 2001)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Not classified - - - - By the description that the ignition points is 240 degC (Hommmel (1991)), it is over 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine and fluorine (but not oxygen) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Diluent type A >=60%, Available oxygen
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Rat LD50=1746 mg/kg (SIDS 1997). As date of rat, 1746 mg/kg, 2410 mg/kg (male), and 1950 mg/kg (female) were corresponded (SIDS 1997). But in consideration of that 1950 mg/kg (female) is not the pure line animal data and an old thing as 1966, it was excluded. From remained two examinations of male, low value of 1746 mg/kg was adopted.
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Rabbit LD50 = 135mg/kg (calculation value) (SIDS 1997). [As data of rats or rabbits, 610mg/kg, 99mg/kg, and 435mg/kg (all are rabbits) corresponded (SIDS 1997), and a calculated value was LD50 = 135mg/kg.]
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Rat LC50 (4h) was classified as Category 2 based on male: 2.4mg/L (486ppm), and female: 2.2mg/L (450ppm) (SIDS (1997)). Since LC50 was lower than 90% of saturated vapor pressure concentration (1158ppm), the gaseous classification Category was applied.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
According to the results of 5 examinations that are made applicable to a classification ('no irritating', 'slightly irritating', 'irritating', 'irritating', and 'irritating') (SIDS (1997)), irritation was seen in four examinations. There is also description of serious erythema accompanied by crust and dropsy on three examples among six in one of the examinations (SIDS (1997)). From what mentioned above, it was classified as Category 2. In addition, it was reported to cause erythema and contact dermatitis on a sweeper who used the floor removing agent that contains high concentrations of this product (SIDS (1997)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Severe irritation is acknowledged by multiple studies using the rabbit (SIDS (1997), ECETOCTR48 (1998)). On the other hand, it is described that although corneal opacity is also sometimes caused with a painful irritation in humans, the symptom is generally recovered within several days (DFGOTvol.6 (1986)). It was set as Category 2A based on these information.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the two negative results of the Maximization test with guinea pigs(SIDS (1997)), and the result of repeated insult patch tests in humans showing [ having no skin sensitization (SIDS (1997)) ], it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - A negative result is obtained in a somatic cell in vivo mutagenicity test (micronucleus test which used the bone marrow cells of the mouse and the rat), (SIDS (1997), CICAD 10 (1998)), and the increase of micronucleus sister chromatid exchanges is not acknowledged in the human epidemiologic survey (ATSDR (1998). Based on these results, we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - It was classified into 3 according to IARC (2004), into A3 according to ACGIH (2003) and into CBD according to EPA (1996), respectively. And the category varies with organizations. Therefore, it carried out the outside of category according to the category 3 by IARC which assessment year is the latest.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since there is description that it is observed of adverse effects in development as decrease implantation count and increase embryo resortions etc. and at the same time of occuring general toxicity as decrease weight gains, change of organs weight and changes in blood parameter on maternal animals in pregnant rat and rabbit organogenetic period exposure test (SIDS (1997)), it was classified into class 2. In addition, although reference is made to the risks of development of cleft palate in a human epidemiologic survey, the relationship with this substance is not clear (PATTY (5th, 2001)).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, blood, kidney, liver), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (central nervous system, blood, kidney, liver)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
In animals, the effect on the erythrocytes is characteristic (SIDS (1997)), but in human, there is the reports not only about the effect to blood such as the decrease of hemoglobin, erythrocytes, and hemoglobinuria, but about the symptoms such as coma, vertigo, dyspnoea, metabolic acidosis, hematuria, unusual liver function (SIDS (1997), PATTY (5th, 2001)). And there is the case which leads to hospital admission (SIDS (1997)). Moreover, the effect to central nervous systems, blood, kidney, liver is mentioned (ICSC (2003)). Considering all the various information together, it is classified into Category 1 (central nervous system, blood, kidney, liver). On the other hand, there is the statement about "a irritation of nose and throat"(SIDS (1997)) in human inhalation test, and the statement about "the irecurrent rritation to respiratory, and a dry cough" in another case paper (HSDB (2004)). So it is classified into Category 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Although there is a report about blood parameter changes after repeated exposure to humans (CaPSAR (1999), HSDB (2004)), the report in particular about serious toxic influence is not found. It was classified to as Category 2 (blood) with reference to the guidance value, and as in the animal studies, toxic effects is admitted to be to blood (red blood cells) in case of inhalation exposure (SIAR 1997, the collection 99-17 of hazard data, IUCLID 2000).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96-hour LC50=5.4mg/L of Crustacea (glass shrimp), and others (CICAD10, 1998).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since rapidly degrading (BOD: 96% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.83 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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