GHS Classification Result

Chemical Name:2-(4-ethoxyphenyl)-2-methylpropyl 3-phenoxybenzyl ether
CAS:80844-07-1

Result:
ID: 675
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since it is indicated that it is stable at 150 degC (DSC) (Agricultural Chemical Registration Data), even if it contacts air at room temperature, it does not ignite spontaneously.
11 Self-heating substances and mixtures Classification not possible - - - - The melting points are 36.4 - 38.0 degC, and 140 degC or less, therefore, the test suitable for a liquid state substance has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: > 42880 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts(1986)
1 Acute toxicity (Dermal) Not classified - - - - Based on rat LD50>2140mg/kg (Agricultural-Chemicals abstracts (1986)) and the description that "having no death" at the same dose, it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Based on rat LC50 >5.9g/m3 = 5.9mg/L (4h) (Agricultural-Chemicals abstracts (1986)), it carried out the outside of Category.
2 Skin corrosion/irritation Not classified - - - - Based on description that it was judged to have no irritation as a result of skin primary irritation examination on rabbits (Agricultural-Chemicals abstracts (1986)), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Based on description that it is judged that there is no irritation to the ocular-mucous of rabbit membrances as a result of the eye primary irritation examination using a rabbit (Agricultural-Chemicals abstracts (1986)), it was set as the outside of Category .
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the negative result of Maximization test using guinea pigs (agricultural chemicals abstracts (1986)), the skin sensitization was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Based on the negative result (JMPR 863 (1993)) in the somatic cell in vivo mutagenicity test (micronucleus examination which used the bone marrow cells of the mouse), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - In the carcinogenicity test by the two-year oral administration using rats and mice, generating of the tumor relevant to a test substance is not acknowledged at all (Agricultural-Chemicals abstracts (1986)). Furthermore, as a result of the evaluation in the residual-agricultural-chemicals safety assessment committee, it had concluded that there is no carcinogenic fear to humans. So it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - It is not observed any effect of reproductive function ant potential with dose causing general toxicity of parent animal in rat three-generation admnistration test (Agricultural-Chemicals abstracts (1985)). Moreover, it is not observed effect on administrated maternal animal (F0) and on reproductie potential of F1 maternal animal in spite of occuring general toxicity to maternal animals in rat organogenetic period administration test (Agricultural-Chemicals abstracts (1985)) and it is judged that there is no teratogenic including the rabbit organogenetic period administration test (Agricultural-Chemicals abstracts (1985)). Since a clear evidence which suggests reproductive toxicity in each test was not admitted, it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Not classified - - - - There are symptoms such as piloerection, fall of a locomotor activity, loose stool more than 42880mg/kg in oral administration in rat, and there are abnormalities of posture and respiratory movement, the statement of lethargica in the highest concentration = 5.9 g/m3 in the inhalation exposure using rat. However, there is no example of death in which course, and it is reported by the end of the observation histopathological inspection that it was normal (Agricultural-Chemical abstracts (1986)). Therefore, acute toxicity was very weak, and the acknowledged effect was also in a dose range beyond a guidance value. So it is classified as the out of the Category.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - It is considered outside of Category according to that in the 13-week oral study using rats and micewith the dose exceeding the maximum of the guidance value range, serious toxic effect is not acknowledged (Agricultural Chemicals abstracts (1986)) and (JMPR 863 (1993)) .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50=3.66microg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=7.05 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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