GHS Classification Result

Chemical Name：Ammonium chloride
CAS：12125-02-9

Result：
ID: 680
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (Weiss, 2nd, 1985; etc.)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (Weiss, 2nd, 1985; etc.)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (Weiss, 2nd,1985; etc.)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification not possible, though inorganic compounds containing halogen.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on the description of LD50=1650 mg/kg in a rat (ACGIH (2002)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 based on the description that as effects of short-term exposure it "stimulates the skin", and as primary disaster / an acute symptoms cause "redness" on humans (ICSC (J) (2000)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is a statement that stimulates an eye by short-term exposure in humans (ICSC (J), (2000)), and that redness and a pain of the eye are caused as the primary disaster / an acute symptoms (ICSC (J), (2000)). With a rabbit, there are an evaluation with mild (ACGIH (2002), RTECS (2005)) and severe (RTECS (2005)), and a statement that although cataract, iridal bleeding, and the appearance of fibrin of the anterior chamber of eye, etc. were seen, it recovered (HSDB (2005)). It was set as Category 2A-2B based on the above information.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there is a statement that the result of the maximization test with guinea pigs was negative(IUCLID (2000)), it was an information of Priority 2 and the only deta on hand, it was decided that it could not be classified due to the insufficiency of data..
5 Germ cell mutagenicity Not classified - - - - Since it gave negative in mice micronucleus test (IUCLID (2000)), we classified it as Out Of Category according to the technical guideline.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is no statement on toxicity to the parents in mice, there is a statement that malformation was observed in their offsprings (HSDB (2005)). Moreover, there is a statement that ovary hypertrophy, follicular maturation, luteal formation, hypertrophy of uterus, hypertrophy of mammilla, and milk secretion were observed in non-crossed female rabbits (EHC 54 (1986)), and there is also a statement that absorbed embryos amounted to one fourth at a dose occuring metabolic acidosis in parent rats (IUCLID (2000)). Based on the above-mentioned, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the description that respiratory is irritated by short-term exposure and the description that inhalation poduces coughs and pharyngeal pain (ICSC (J) (2000)), it is classified into Category 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (systemic toxicity) Danger H372: Cause damage to organs through prolonged or repeated exposure (systemic toxicity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 1 (systemic toxicity) based on the statement that metabolic acidosis was occured in humans (ACGIH (2002)). In addition, although there is no statement of dosage, there is a description that also in a rat, a rabbit, and a dog, osteoporosis is produced by long-term administrations, and the cause is metabolic acidosis (EHC 54 (1986)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=0.696mg NH3/L (ammonium-chloride concentration equivalent: 2.19 mg/L) of fishes (Rainbow trout) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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