GHS Classification Result

Chemical Name：sulfotep
CAS：3689-24-5

Result：
ID: 686
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Although it was combustible, since the data on flash point was not found, based on the UNRTDG class 6.1, it was considered as out of Category.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Not classified based on UNRTDG Class: 6.1, though containing P-O bonds as chemical groups associated with self-reactive properties present
9 Pyrophoric liquids Not classified - - - - Based on the UNRTDG class 6.1, it carried out the outside of Category.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - Not classified because of UNRTDG Class: 6.1 though containing oxygen bonded to other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is a statement (Merck (13th, 2001)) of corroding steel, since there is no rest of database, it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on LD50=5.35 mg/kg. This value was calculated by ten data of rats(ACGIH(2005), DFGOT vol.13(1999)).
1 Acute toxicity （Dermal） Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LD50 = 262mg/kg (ACGIH (2005), DFGOT vol.13 (1999)), was compared with the lower LD50 = 5mg/kg among rabbit two data (ACGIH (2005), DFGOT vol.13 (1999)). And it was set as Category 1 based on the lower LD50 = 5mg/kg.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since the saturated vapor pressures concentrations pressure of this product is 0.2ppm, it is thought that the inhalation experiments was conducted in mist conditions. Based on LC50 = 0.038mg/L which is lower value among two rat data (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)), it was set as Category 1.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There are results that skin irritation was not observed on rabbit (ACGIH and (2005), DFGOT vol.13 (1999), and PATTY (5th, 2001)), however, there are many descriptions on humans that it stimulates skin and causes disorder (ACGIH (2005), ICSC (J), (1999), HSDB (2005), HSFS (2000), SITTIG (2002)). Since there was no statement about the disorder and concrete description or a grade of the stimulativeness on humans, taking the larger side with danger, it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on a statement although a stimulus and redness were acknowledged in the eye with the rabbit, it recovered within 24 hours (ACGIH and (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)), and that an eye was stimulated in humans and pains and blurred visions were produced (ICSC (J), (1999), HSFS (2000), SITTIG (2002)), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was a statement that contact dermatitis was produced by chronic exposures in humans(HSDB (2005)), it was the only statement on hand and the number of cases was unknown. Therefore, it was decided that it could not be classified due to the insufficiency of data..
5 Germ cell mutagenicity Not classified - - - - We found no results of human over generation epidemiology, and it gave negative for the dominant lethality examination with the mouse (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001), negative for the micronucleus test with mouse bone marrow cells (DFGOT vol.13 (1999), PATTY (5th, 2001)). Therefore we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Based on being classified into A4 according to ACGIH (ACGIH (2005)), it considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is observed that no effects on reproduction of parents and development and growth of offsprings in multiple organogenetic period administration tests in rats and rabbits(ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)) and in a rat two-generation administration test (DFGOT vol.13 (1999), but it is observed increase empryo absortion and decrease fetal weight at dose occuring toxicity on maternal animal in one rat organogenetic period administration test (DFGOT vol.13 (1999)). Based on this data, it was classified into class 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In many studies using rat, mouse, rabbit, dog and cat, there is the description about the symptoms of typical organophosphorus compound toxicity, and inhibition of cholinesterase in the central and peripheral nerve, in the dose in the range of the guidance value of Category 1 (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)). There is the description about the symptoms of phosphororganic compound toxicity as headache, malevolence/vomiting, diarrhea, dizziness, weakness, muscular pain, anxiousness, closeness, salivation, lachrymation, drowsiness in human (ACGIH (2005), PATTY (5th, 2001)). Moreover, there is a description that "stimulating lungs and producing coughing and closeness in the inhalation" at humans (HSFS (2000)). It is classified into Category 1 (nervous systems) and 3 (respiratory irritation) from the above thing.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, lung) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 1 (nerve systems) based on that in oral study to rats and dogs, with the dosage of guidance value within the limits of Category 1, cholinesterase inhibition in red corpuscles and/or plasma and relevant symptoms such as the convulsion, tremor, vomiting and diarrhea etc., were observed (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)). Moreover, it was classified to as Category 1 (lungs) based on that in the rat inhalation test with the dosage of guidance value within the limits of Category 1, pulmonary edema and relevant the increase in weight (absolutely weights and relative weights) of the lungs is observed (ACGIH and (2005),DFGOT vol.13 (1999) and PATTY (5th, 2001)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour LC50=0.23microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.99(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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