GHS Classification Result

Chemical Name：Benzene, 1-methoxy-2-nitro-
CAS：91-23-6

Result：
ID: 697
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified in UNRTDG Class: 1
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - It is not classified into the un transportation dangerous class 4.1 although it has a nitro group. If decomposition heat is less than 300 J/g or SADT is more than 75 degC, it will become "Outside Category", but the data is not found. There is potential of "Class G".
9 Pyrophoric liquids Not classified - - - - Not Classified in UNRTDG Class: 4.2
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - Not classified in UNRTDG Class: 5.1, though containing oxygen bonded to nitrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available on tests

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Since rat oral toxicity average value was 740mg/kg, it was set as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - There was no nonsurviving animals at 2000mg/kg in the dermal exposure experiment of rats. And there was also no serious acute toxicity report. So it was set as outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Since the skin irritation was not observed in rabbit examination (DFGOT vol.9 (1998)), it was classified as "out of Category."
3 Serious eye damage/eye irritation Not classified - - - - There is slight irritation by the examination of a rabbit and it had recovered within 24 hours (DFGOT vol.9 (1998)). It was judged that it did not correspond to Category. BUA140 (1993) is also judged about the same experiment to be "no irritant."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		We found no in vivo data, however, we have not a little in vitro mutagenicity test data, and these findings are thought to show the mutagenicity positivity in multiple indices clearly. So we classified it as "Category 2".
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		IARC had judged with "2B" in the monograph 65 in 1996 and it was set as "2." Although set to "Category 1B" from the category 2 of EU, the judgment of IARC was adopted according to notes of guidance.
7 Reproductive toxicity Not classified - - - - Effect was observed in the pregnant rat oral administration test. Moreover, it is reported of effect on male genitalia in oral administration test for 13 weeks at high dose (DFGOT vol.9 (1998)). Since there was no teratogenic, and there was no clear description of affecting to female genitals at lower dose of general toxicity, it was considered as "Category Outside." (It is based on an experts ' comments)
8 Specific target organ toxicity - Single exposure Classification not possible - - - - There is no validate test data and it cannot be classified. There is the description about "dyspnoea/piloerection" as finding of an acute fatality test (RTECS (2005)).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood, liver, spleen, urinary bladder) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood, liver, spleen, urinary bladder) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as "Category 2" because the bad influences, such as hemolytic anemia and internal organ weights etc., are observed in oral repeated exposure for four weeks or more to a rat (more than 40mg / kg/day) (DFGOT vol.9 (1998)).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data on chemical pneumonia

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 24-hour EC50=59mg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Based on NOEC=13 mg/L during 21 days of the shellfish (Daphnia magna) (ECETOC TR91, 2003), though acute toxicity was Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information