GHS Classification Result

Chemical Name：Phthalonitrile
CAS：91-15-6

Result：
ID: 698
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: >580degC (ICSC, 2004)
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rat LD50= 86.1mg/kg. This value was calculated by four data (85mg/kg, 85 mg/kg, 125 mg/kg, and 125 mg/kg) (the Health, Labor and Welfare Ministry reports (2005), SIDS (2001)).
1 Acute toxicity （Dermal） Classification not possible - - - - Although there are data (IUCLID (2000)) of rat, rabbit and cat, since test concentration of rat is unknown. LD50 value is not obtained in both rabbit and cat, it cannot be classified due to the insufficient data.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Since LC50 is not obtained with saturated vapor pressure concentration (39.6ppm) in seven data (SIDS (2001), IUCLID (2000)), it cannot be classified due to data insufficiency.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Slight irritation was reported for the 24-hour test on guinea pigs. But based on the results that irritation was not observed in four rabbit examinations (SIDS (2001), IUCLID (2000)), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Since irritation was not seen by the test (SIDS (2001), IUCLID (2000)) using a rabbit, it was carried out the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the negative result (SIDS (2001)) by the in vivo micronucleus test of the mouse and lymphocyte chromosomal analysis of the exposed humans (somatic cell in vivo mutagenicity test), we classified it as Out Of Category.
6 Carcinogenicity Classification not possible - - - - Although the tumor was seen by the examination (SIDS (2001)) of a rat and a mouse, it is reported that the frequency of origin of controls is not indicated. Although a tumor is looked at by the rat at IUCLID (2000), it is indicated that it is too inadequate data. Therefore, since data was insufficient, it was presupposed that it cannot classify.
7 Reproductive toxicity Not classified - - - - Based on not observing of reproductive toxicity in rat administration test (Ministry of Health, Labour and Welfare (2005), SIDS (2001)) , it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the movement disorder in t wo tests n the concentration in the range of the guidance value in the Category 1(the Health, Labor and Welfare Ministry reports (2005), RTECS (2004)). And there is spasm in one test (IUCLID (2000)). Vertigos, nausea, vomiting, headaches, unconsciousness, and epileptic episode were reported by exposure of humans (SIDS (2001)). It is classified into Category 1 (nervous system) based on these descriptions.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although some effects were observed to the liver and the kidney in the combined test of two reproduction tests (the Ministry of Health and Welfare (2005), SIDS (2001)), affect against specific organ is not seen in other three examinations (IUCLID (2000), SIDS (2001)). However, each examination was in the dosage of guidance value within the limits of Category 1, and since any test did not have higher-dose data, it was considered that it cannot be classified.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour LC50=22.6mg/L of fishes (Oryzias latipes) (SIDS, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 3.3% (existing chemical safety inspections data)), though less bio-accumulative (BCF=1.3 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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