GHS Classification Result

Chemical Name：Cyanamide, calcium salt (1:1)
CAS：156-62-7

Result：
ID: 701
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although pure form is nonflammable (Merck, 13th, 2001), it may also be considered that if content of carbon as production increases, it may become flammable. [Note] Although calcium cyanamid with the content of calcium carbide being less than 0.1% contains combustible component carbon, there is no UN number and it does not correspond to a hazardous materials. So it is outside Category.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and mainly used as agricultural chemicals.
11 Self-heating substances and mixtures Not classified - - - - A pure forms is nonflammable (Merck, 13th, 2001) and outside Category. Moreover, UNRTDG is classified into 4.3 and III when the content of the carbonized calcium (calcium carbide) which is the impurities on manufacture exceeds 0.1% (UN number 1403). 4.2 is not attached. As mentioned above, it was judged as the outside of Category.
12 Substances and mixtures which, in contact with water, emit flammable gases Category 3 or Not classified Warning H261: In contact with water releases flammable gas P231+P232: Handle under inert gas. Protect from moisture.
P370+P378: In case of fire: Use ... for extinction.
P402+P404: Store in a dry place. Store in a closed container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		It reacts with water and flammable gases acetylene and ammonia are produced (HSDB, 2003). When the content of carbonized calcium (calcium carbide) which is manufacturing impurities exceeds 0.1% (UN number 1403), UNRTDG is classificationed into 4.3 and III and corresponds tocategory 3, but When other, it is outside Category.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was set as Category 4based on the lower value (403mg/kg). This lower value were adopted from LD50 value of 1958mg/kg (4300mg/kg/purity 45.54%) and 403 mg/kg (700mg/kg/purity 45.54%) converted 100% of sample purity of the oral administration examination using rats (Agricultural Chemical Registration Data (2000))..
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Since in the rat acute percutaneous toxicity studies which administered up to 2800mg/kg (100% purity reduced value: 1640mg/kg), fatal cases is observed in male at highest dose (purity reduced value: 1640mg/kg) but not observed in female (pesticide registration application samples (2000)). it was guessed that LD50 value was in the dose ranges exceeding Category 4 (1000 - 2000mg/kg), and it was set as Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. About inhalation, there is description of "LC50 are maximum allowable concentrations, and 13g or more of 50% aqueous solutions of calcium cyanamide per m3" (Agricultural Chemical Registration Data (2000)). And LC50 became >6.5mg/L (mist), it was set as Category 5.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the diffuse nature expansive redness and itchiness on human skin and formation of induration, ulcer, and crust on rabbit skin since (Agricultural Chemical Registration Data (2000)), and it was classified as R38 in EU-Annex, it was classified as Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since pH of the soil suspensions of calcium cyanamide was classified into more than 11.5 (Agricultural Chemical Registration Data (2000)) and R41in EU-Annex I (Access in 2006), it was set to Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the negativity of the mouse bone marrow micronucleus tests and Ames examination carried out up to 1000 microg/plate (Agricultural Chemical Registration Data (2000)), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - From the negativity in mouse and rat carcinogenicity test (Agricultural Chemical Registration Data (2000)), it carried out the outside of category.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (systemic toxicity)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Although there is the toxic symptom such as decrease of the amount of locomotor activity, prostrate, irregular respiration, trembling, the fall of body temperature, anemia, abasic, deconditioning of respiratory in rat dermal acute toxicity test (Agricultural Chemical Registration Data (2000)), it is not obvious the relationship with dose. And considering that male is 2000mg/kg (purity equivalent of 1172mg/kg), and female is 1000mg/kg (purity equivalent of 586mg/kg) about the amount of non toxic of this test, and the difficulty of specifying the target organs. So it is generally considered as in the guidance value of the Category 2, it is classified into Category 2 (general toxicity). Moreover, in the rat inhalation acute toxicity test, the inflammation of a respiratory way, pharyngitis, and a tracheal gill flame occured. So it is classified into Category 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Since the non-neoplastic lesions which originates in the this product is not acknowledged in a mouse and rats carcinogenicity test, and regarding occupational exposures of calcium cyanamide, there is no basis considered to be caused by calcium cyanamide about all of acute or chronic disease up to the level of 8mg CaCN2/m3 (Agricultural Chemical Registration Data (2000)), it considered that data is insufficient and it cannot be classified.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=7.7mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2, and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=-0.2(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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