GHS Classification Result

Chemical Name：Xylidine
CAS：1300-73-8

Result：
ID: 704
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		There was no report as an isomer mixture. But rats of each isomer and LD50 value were within the limits of 470mg/kg to 1270 kg/kg, it was classified into Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was classified into Category 4 since there were description of rat LD50: 2000mg/kg and rabbit LD50: 1500mg/kg (DFGOTvol.19 (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is no report of an isomer mixture. There is a data of mouse LC50: 149ppm/7h for 2, 4-Xylidine (ACGIH (2002)). The saturated vapor concentration at 25degC is 180ppm (0.89mg/L), and it is thought that LC50 value in this test is steam. Since it was converted to 197ppm for 4h, it was classified as Category 2.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There is no report of an isomer mixture. There is data of rat LC50: 1.53mg/L (DFGOTvol.19 (2003)) about 2, 4-Xylidine. The concentration of the saturated vapor at 25degC is 180 ppm (0.89mg/L), and 1.53mg/L is considered to be mist. And if it is exposure for 4 hours, it is equivalent to category 2. However, there is no publication of exposure time, it cannot be classified by this data.
2 Skin corrosion/irritation Not classified - - - - There was no report of a mixture. It was classified as out of Category from the statement of having no stimulativeness in the rabbit test with 2,4 isomer (DFGOTvol.19 (2003)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is no report with a mixture, and although there is a stimulative (DFGOTvol.19 (2003)) statement by the examination of the rabbit of 2,4 isomer, its recovery is unstated, so it cannot to set as Category 2A or 2B. It is more desirable to set to 2A from a viewpoint of safety if subdivision is required in a display etc.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - For in vivo tests, we found the findings that 2,6 isomer gave negative by mouse micronucleus assay (ACGIH (2002)), and for in vitro examination we found the statement that all the isomers gave the positive by the Ames test (they had metabolic activity), and with the eucaryotic cells, 2,4 isomer and 2,5 isomer induced DNA repair, 2,4 isomer (without the metabolic activity) and 2,6 isomer (with metabolic activity) induced the chromosomal abnormalities, 2,4 isomer gave positive in comet assay (DFGOTvol.19 (2003)), and 2,6 isomer showed positive in the chromosomal aberration test with the CHO cell (ACGIH (2002)). However, there was no report of the in vivo examination with the mixture of this product, therefore we could not classify it.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Classified in "A3" (ACGIH)
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There is the description that pulmonary congestion occurs of the below 2.2mg/L of inhalation exposure (mist) in the guidance value of the category 2 in the test of rat about 2,4 isomer (DFGOTvol.19 (2003)). And there is the anesthetic action in the 1.06mg/L/4h of inhalation exposure in the guidance value of the Category 2 in the mouse test of isomer mixture (DFGOTvol.19 (2003)). And there is the irritation to nose in the above 0.5mg/L inhalation exposure in the rat test of 2,4 isomer (DFGOTvol.19 (2003)). So it is classified into Category 3 (anesthetic action). And about respiratory irritation, include disorder of lung above, it is classified into Category 2 (respiratory tract system).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood, liver, kidney, gallbladder, spleen) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood, liver, kidney, gallbladder, spleen) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified as to Category 2 (blood) according to the statement which causes methemoglobinemia to humans (HSDB (2005))(priority 2). About methemoglobinemia, there is also a report of the inhalation atmospheric exposure test of a rat, a mouse, a dog and a rabbit (ACGIH (2002)), and the oral study of a rat 7(DFGOTvol.19 (2003)). Furthermore, although there is no isomer mixtures' test reports, there are some statements; by oral administration to a rat of 2.4, 2.6 isomers of 157mg/kg each for 20 days (90-day conversion : 35mg/kg), 2.4 isomer had a disorder in the liver, the kidney, and the gallbladder and 2.6 isomer had a disorder in the spleen(ACGIH (2002)); by oral administration of 2.6, 2.4, and 2.5 isomer by 50mg/kg/4W (90-day conversion : 17mg/kg) to a dog had a liver damage (ACGIH (2001)); in inhalation exposure of 0.1-0.3 mg/L for 28 days (90 day conversion: 0.03-0.1 mg/L) to the rat of 2.4 isomer, it had a disorder in the liver and the spleen(DFGOTvol.19 (2003)). Since these dose and exposure concentrations were within the guidance value of 2, it was categoried into Category 2(liver,kidney,gallbladder, spleen).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information