GHS Classification Result

Chemical Name：Creosote
CAS：8001-58-9

Result：
ID: 706
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified in UNRTDG Class: 1
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 4 because of its flash point: 60 to 93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Not classified in UNRTDG Class: 4.1
9 Pyrophoric liquids Not classified - - - - There is data that the ignition points is 330 - 500 degC, and it is thought that it does not ignite in room temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - There is the information (Merck (13th.2001)) that is substantially insoluble in the water, and it is thought that there is no intense reaction with water.
13 Oxidizing liquids Not classified - - - - UNRTDG Class: Not 5.1
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not classified - - - - UNRTDG Class: Not 5.2
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Since the mean of five rat oral LD50 data (CICADS 62 (2004)) were 1523mg/kg, it was set as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - It was set as outside of Category since there were the data (ATSDR (2002)) that the half was lethal at 15800mg/kg in rats.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There were differences in the result according to the creosote material coal place of produc. But there was a report of moderate stimulation about the American product (ATSDR (2002)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is one report that stimulative is in rabbit eye. But it had recovered within seven days (CICADS 62 (2004)). So it was set as "Category 2B."
4 Respiratory sensitization Classification not possible - - - - There is no data on respiratory sensitization.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There is allergic reactions reports of humans about skin sensitization. The hypersensitivity against ultraviolet lights is also mentioned (CICADS 62 (2004)). It was referred to as Category 1, based on these information.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The result of the in vivo test of mouse somatic cells (a bone marrow micronucleus, splanchnic organizations DNA adduct) was positive (CICADS 62 (2004)), however, there was no In vivo test result about the reproductive cell. So we classified it as Category 2.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as "Category 1B" from the judgment result of IARC: 2A, Occupational Health Society: 2A, EPA: B1, and EU: Cat.2.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since increase of brain tumor and neuroplastoma was suggested to the posterity of the male laborers who received creosote exposures (CICADS 62 (2004)), it is classified into "Category 1A."
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since the anesthetic actions was seen by test in animal rats (CICADS 62 (2001)) and there was information on the human respiratory irritation (HSDB (2003)), it is classified into Category 3.
9 Specific target organ toxicity - Repeated exposure Category 2 (lung, liver, kidney, blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (lung, liver, kidney, blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There is no crucial impact at oral 50mg/kg/day (15w) in rats (within the range of the guidance value Category 2) (CICADS 62 (2004).). Since the histiocytoses of lungs, increase of weight of liver and the kidney (male) and blood (reduction of red corpuscles and hemoglobin, increase in a reticulocyte) were seen in the examination of mist inhalation (ATSDR (2002)) in guidance value within the limits of 2, it was classfied to as "Category 2 (lungs, liver, kidney, blood)."
10 Aspiration hazard Classification not possible - - - - We could not find the competent evidence for human. As dynamic viscosity applies to Category 1, 2, however, the principal component is polyaromatic compound, and it is not a substance which has statements of chemical pneumonia in ICSC. We cannot classify it for the dearth of information.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.018mg/L of Crustacea (Mysid shrimp) (CICAD62, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, and rapid degradability and bioaccumulation potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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