GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：chlorophenol
CAS：25167-80-0
Result：
| ID: | 712 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable (o, m, p-) | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule (o-, m-, p-). |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable (o, m, p-) | - | - | - | - | Not Gas (GHS definition) (o-, m-, p-) |
| 3 | Aerosols | Not applicable (o, m, p-) | - | - | - | - | Not aerosol products (o, m, p-) |
| 4 | Oxidizing gases | Not applicable (o, m, p-) | - | - | - | - | Not Gas (GHS definition) (o, m, p-) |
| 5 | Gases under pressure | Not applicable (o, m, p-) | - | - | - | - | Not Gas (GHS definition) (o, m, p-) |
| 6 | Flammable liquids | Category 4 (o-), Not applicable (m, p-) | - | Warning | H227: Combustible liquid (o-) |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Category 4 because of its flash point: 64degC (closed cup) (o-). Solid (GHS definition) (m, p-) |
| 7 | Flammable solids | Not applicable (o-), Classification not possible (m, p-) | - | - | - | - | Liquid (GHS definition) (o-) No data available (m, p-) |
| 8 | Self-reactive substances and mixtures | Not applicable (o, m, p-) | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties present (o-, m-, p-) |
| 9 | Pyrophoric liquids | Classification not possible (o-), Not applicable (m, p-) | - | - | - | - | No data. (o-body) It is a solid by the definition of GHS. (m-body, p-body) |
| 10 | Pyrophoric solids | Not applicable (o-), Not classified (m, p-) | - | - | - | - | It is a liquid according to the definition of GHS. (o-body) It was judged that it did not ignite spontaneously from the fact that the measurement of flash point was performed at the temperature of 112 degC or more (ICSC (1999)). (m-body, p-body) |
| 11 | Self-heating substances and mixtures | Classification not possible (o, m, p-) | - | - | - | - | The test suitable for a liquid state substance is not established. (o-body) The test suitable for a solids material is not established. (Solid with a melting point of 140 degC or less) (m-body, p-body) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable (o, m, p-) | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)(o, m, p-) |
| 13 | Oxidizing liquids | Not applicable (o, m, p-) | - | - | - | - | Organic compounds containing oxygen and chlorine (but not fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements) (ortho). Solid (GHS definition) (meta, para). |
| 14 | Oxidizing solids | Not applicable (o, m, p-) | - | - | - | - | Organic compounds containing oxygen and chlorine (but not fluorine) and the oxygen and chlorine are chemically bonded only to carbon and hydrogen (but not to other elements) (meta, para). Liquid (GHS definition) (ortho). |
| 15 | Organic peroxides | Not applicable (o, m, p-) | - | - | - | - | Organic compounds containing no -0-0- structure (o-, m-, p-) |
| 16 | Corrosive to metals | Classification not possible (o, m, p-) | - | - | - | - | No data available (o, m, p-) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | o-: Category 4, m-: Category 4, p-: Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
O-object: lower LD50= 670mg/kg was adopted between two data (the Health, Labor and Welfare Ministry reports (2005), EHC 93 (1989)) of rat LD50 values, and it was set as Category 4. M-object: It was set as Category 4 based on rat LD50= 570mg/kg (EHC 93 (1989)). P-object: It was set as Category 3 based on rat LD50= 261mg/kg (EHC 93 (1989)). |
| 1 | Acute toxicity （Dermal） | o-: Category 4, m-: Classification not possible, p-: Classification not possible |
|
Warning | H312: Harmful in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
O-body: It was set as Category 4 based on rabbit LD50 = 1000 - 1580mg/kg (ATSDR (1999)). M-body: no data. P-body: no data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | o-body is liquid, m-body and p-body are solids, respectively according to the definition of GHS. |
| 1 | Acute toxicity （Inhalation: Vapours） | o-: Category 2, m-: Classification not possible, p-: Classification not possible |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
o-body: saturated vapor pressure concentration is 2277ppm (11.98mg/L). And it was classified as Category 2 based on rat LC50 = 389.5ppm (converted from 2.05mg/L) (ATSDR (1999)) obtained from the test considered to have been performed with vapor. m-body: No data. p-body: No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | o-: Classification not possible, m-: Classification not possible, p-: Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on mouse LC50=49 mg/L (DFGOT vol.1 (1991)) of the inhalation test carried out in mist, it carried out the outside of Category. O-body: datum without. M-body: datum without. P-body: saturated vapor pressure pressures concentrations is 128.7ppm (0.677mg/L), and it was set to category 4 based on rat LC50 = 1.01mg/L (IUCLID (2000)) obtained by the test considered that the dust performed. |
| 2 | Skin corrosion/irritation | o-: Category 1A-1C, m-: Category 2, p-: Category 1A-1C |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
o-body: It was classified as Category 1A-1C based on the statements that serious stimulativeness and corrosion were observed on rabbits (ATSDR (1999)) and that there were redness and pain on humans (ICSC (J) (1999)). m-body: It was classified as Category 2 based on the statement that there are redness and pain on humans (ICSC (J) (1999)). p-body: It was classified as Category 1A-1C based on the statements that there were serious stimulativeness and corrosiveness for animals (ATSDR (1999), RTECS (2004), and IUCLID (2000)) and that there are redness and pain on humans (ICSC (J) (1999)). In addition, monochlorophenol is reported to have corrosivity on animals (ATSDR (1999)). |
| 3 | Serious eye damage/eye irritation | o-: Category 1, m-: Category 2A-2B, p-: Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
O-body : it is a skin corrosive substance, and there is a statement that significant discomfort and corrosion were seen with the rabbit (ATSDR (1999)), and that redness, a pain, and a haze eyes were seen with humans (ICSC (J), (1999)). So it was set as Category 1. M-body: It was set as Category 2A-2B based on the statement that redness, a pain, and a haze eyes were seen with humans (ICSC (J) (1999)) . P-body: it is a skin corrosive substance, and there is a statement that caustic was seen with the rabbit (RTECS and (2004), IUCLID (2000)), and that redness, a pain, and a haze eyes were seen with human (ICSC (J) (1999)). So it was set as Category 1. |
| 4 | Respiratory sensitization | Classification not possible (o, m, p-) | - | - | - | - | o-object: no data, m-object: no data, p-object: no data |
| 4 | Skin sensitization | Classification not possible (o, m, p-) | - | - | - | - | o-object: no data, m-object: no data, p-object: no data |
| 5 | Germ cell mutagenicity | o-: Not classified, m-: Classification not possible, p-: Classification not possible | - | - | - | - | O-body : There was no positive finding in any of human over generation epidemiology, over generation mutagenicity test, in vivo mutagenicity test of the productive cells and the somatic cells, and based on the statement (ATSDR (1999)) that it gave negative in the in vivo sister chromatid exchange tests using the mouse spermary cells and marrow cells, and on the statement (IUCLID (2000)) that it gave negative for the in vivo mouse micronucleus assay. So we classified it as Out Of Category according to the technical guideline. m-body: No data. p-body: Based on the fact that there being no in vivo test results and there being no strong positive in vitro examination results in multiple indices So we presupposed that we could not categorize it according to the technical guideline. |
| 6 | Carcinogenicity | o-: Category 2, m-: Classification not possible, p-: Classification not possible |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
O-body: It was set as Category 2 based on what is classified into 2B in Japan Society for Occupational Health (JETOC specially data No.190 (2004)). M-body: datum without. P-body: datum without. |
| 7 | Reproductive toxicity | o-: Category 2, m-: Classification not possible, p-: Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
O-object: Since with the rat and the mouse, although there was no descriptions of general toxicity on parental animals, there was the description of decrease of litters count and increase conception rate and stillborn pups count (IRIS (2005) and EHC 93 (1989)), it was classified into Category 2. M-object: no data. P-object : Since with rats and mice, although there is no descriptions of general toxicity on parental animals, there was description of effects on spermatogenesis (genetic factor, spermatozoa morphology, sperm motility and sperm count), increase postimplantation lethality, embryotoxicity, fetotoxicity and fetal death (RTECS (2004)), it is classified into the Category 2. |
| 8 | Specific target organ toxicity - Single exposure | o-: Category 1 (central nervous system), Category 3 (respiratory tract irritation), m-: Classification not possible, p-: Category 1 (central nervous system), Category 3 (respiratory tract irritation) |
|
Warning Danger |
H370: Causes damage to organs (central nervous system) H335: May cause respiratory irritation (central nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
O-body: In the dose of guidance value within the Category 1, in rats and mouse, there are backward curvature, a woolen handstand, excitement, a respiratory promotion action, the signs of an eye stimulus, the excess of saliva, thrill and convulsion (ATSDR (1999), RTECS (2004), IUCLID (2000)), and in humans, there are lethargica, a sense of weakness and convulsion (ICSC (J) (1999)). It is classified into Category 1 (central nervous systems) based on these. And there are stimulation of the nasal mucosa is indicated by the rat (IUCLID (2000)), and a cough, breathlessness, and pharyngalgia are indicated in humans (ICSC (J) (1999)). It is classified into Category 3 (respiratory irritation) based on those. M-body: datum without. P-body: By the dose of guidance value within the Category 1, in a rat, there are the description that there are a droopy eyelid, blood vessel extension, polypnea, dyspnoea, the low response to a sound stimulus, clonic convulsion, and decubitus position (IUCLID (2000)), and in human, there are dizziness, headache, closeness, feeling of sickness, vomiting, a weakness, and unconsciousness (ICSC (J) (1999), IUCLID (2000)). So it is classified into Category 1 (central nervous systems). And there is the statement (ICSC (J), (1999), IUCLID (2000)) that a cough, pharyngeal pain, and mucosa stimulativeness are seen by humans. It is classified into Category 3 (respiratory irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | o-: Category 2 (central nervous system, liver), m-: Classification not possible, p-: Category 2 (central nervous system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
O-object : It was classified to as Category 2 (central nervous systems,liver) based on the statement that in rats and mouse, with administration of guidance value within the limits of Category 2, tremorg, reduction of operant behavior, hypersalivation, hyperkinesia, reduction of brain weight, the increase in liver weight, hepatocellular hypertrophy, and hepatocytes are observed (the Health, Labor and Welfare Ministry reports (2005), ATSDR (1999)) . M-object: no data. P-object: It was classified to as Category 2 (central nervous systems) based on the statement that sleep disorders (sleepiness or insomnia), excitability, mood disorders, and a rapid fatiguability were observed in humans (IUCLID (2000)). |
| 10 | Aspiration hazard | o-: Classification not possible, m-: Classification not possible, p-: Classification not possible | - | - | - | - | No data available (o-, m-, p-) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |