GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Distillates (petroleum), straight-run middle
CAS：64741-44-2
Result：
| ID: | 716 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | UNRTDG No. 1202, Class: 3 |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (room temperature) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (room temperature) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (room temperature) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Category 3 based on UNRTDG Class: 3, PG3 |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (room temperature) |
| 8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | Classified in UNRTDG No. 1202, Class: 3 |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: >177degC(>70degC) (EHC171(1996)) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (room temperature) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | UNRTDG class3 No.1202 |
| 13 | Oxidizing liquids | Not classified | - | - | - | - | UNRTDG No. 1202 Class: 3 |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (room temperature) |
| 15 | Organic peroxides | Not classified | - | - | - | - | UNRTDG No. 1202 Class: 3 |
| 16 | Corrosive to metals | Not classified | - | - | - | - | UNRTDG No.1202, Class: 3 |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Not classified because of SPECIES: Rat; ENDPOINT: LD50; > 5000 mg/kg bw; REFERENCE SOURCE: EHC (1996) |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | Considering rat dermal LD50 >2000, > 5000 mg/kg (EHC (1996)), it was set as Category which is lower toxicity from Category 3. But it could not be decided, it cannot be classified. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (room temperature) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Inhalation study of gasoline was done that aerosol is mixed with steam, it was thought that aerosol is main. And It was set as Category 4 based on value 4.6mg/L (IUCLID (2000)) that is lower value of rat inhalation LC50. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was highly irritating in rabbit skin irritation tests. But it was classified as Category 2 because description of irreversible lesions is not observed (IUCLID (2000), EHC (1006)). |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the statement of slightly irritating (IUCLID (2000)) by the tests for rabbit eye irritation, it was set as Category 2B. This Category is also supported by the case report in human (eye irritation recovers in four days and injection recovers in 24 hours). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Since there is no data, it cannot be classified. |
| 4 | Skin sensitization | Not classified | - | - | - | - | It was put outside of the division, based on the fact that the skin sensitization was not identified in the skin sensitization test with guinea pigs(IUCLID (2000), EHC (1996)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the negative results in the mice dominant lethality tests and in the rat myeloid cell chromosomal aberration tests (IUCLID (2000)), we classified it as Out Of Category. |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as 2 based on the category A3 by ACGIH. [special notes] EU has classified diesel fuels into category 3 (it will be Category 2 if a technical guide is obeyed), and desulfurization gas oil into a category 2 (it will be 1B if a technical guide is obeyed). Each of these is considered to be the classifications corresponding to gasoline. On the other hand, IARC classifies with a group 3 to Distillate(light) diesel fuel, and this will become the outside of Category if a technological direction is obeyed. As a result, category of light oil is distributed to 1B, 2, and out of category. By this classifications, the Japanese properties of diesel fuel was also taken into consideration, and it was set as 2. |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Since there was no significant effect to the reproductive function and reproductive potential, and the development of neonatal in the rat administration test to female in premating and conception, during gravid period, and to male(ACGIH (2003)), it was considered as on the outside of Categry. This classification is supported also because it is not observed developmental toxicity in other test of pregnant rat administrated (EHC (1996)).. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (kidney), Category 3 (respiratory tract irritation, narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (kidney) H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
In the case in which gasoline was exposed in large quantities in humans, there are progressive oliguria and acute tubular necrosis (EHC (1996), ATSDR (1995)), it is classified into category 1(kidney). And based on investigation report of lethargica, coma by kerosene oral ingestion in human (ATSDR (1995)), it is classified into Category 3 (anaesthetic). Moreover, it is classified into Category 3 (respiratory irritation) based on the statement which stimulates a respiratory tracts (ICSC (2004)). In addition, lungs injury by aspiration was classified according to vacuum respiratory toxicity information. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified to as Category 1 (kidney) since that the acute renal tubular necrosis (EHC (1996), ATSDR (1995)), the acute renal damage accompanied by anemia and thrombocytopenia, etc. are reported in repeated exposure to humans (EHC (1996)). |
| 10 | Aspiration hazard | Category 1 |
|
Danger | H304: May be fatal if swallowed and enters airways |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P331: Do NOT induce vomiting. P405: Store locked up. P501: Dispose of contents/container to ... |
Category 1 because of "possible to cause chemical pneumonia by misswallowing of the liquid." (ATSDR, 1995) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |