GHS Classification Result

Chemical Name:Butyl acetate
CAS:123-86-4

Result:
ID: 726
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: 22degC, Boiling point: 126degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - It is danger of fire (class3) in the UN Recommendations.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3 (flammable)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - There is information that it can carry with a metal container by IMDGcode (Packing Instruction is P001).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - The rat oral toxicity value was 14.13g/kg (ACGIH (2001)), and it was set as the outside of Category.
1 Acute toxicity (Dermal) Not classified - - - - Since the rabbit dermal toxicity value was 17,600mg/kg (RTECS (2004)), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified as Category 3 with the rat inhalation toxicity value of 2000ppm (ACGIH (2001)). Since it was 90% or less of saturated vapor concentrations, it was classified based on gas standard value.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was set as Category 4 based on the rat inhalation test toxicity value of 391ppm (1.85mg/L) (ACGIH (2001)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since there was a report of mild skin irritation on humans (ACGIH (2001)), it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Corneal opacity recovery on the second day, iris was not seeing impact, and redness of the conjunctive had recovered on the 7th day and 14th day. So it was taken as Category 2B.
4 Respiratory sensitization Classification not possible - - - - It was decided that it could not be classified since there is no data.
4 Skin sensitization Not classified - - - - Since the 3rd volume of MOE Risk Assessment (2002) does not recognize skin sensitization, it was put outside of the Category.
5 Germ cell mutagenicity Classification not possible - - - - In the in vitro examination it gave the negative result, however, there was no in vivo test result. Therefore we presupposed that we could not classify it according to the technical guideline.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Not classified - - - - MOE Risk Assessment The 3rd volume (2002) and ACGIH (2001) are coming from the same reference. Since significant differences were not observed as compared with the control, it was assumed as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 2 (lung), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (central nervous system)
H371: May cause damage to organs (lung)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Pulmonary edemas was seen by the central nerves Category 1in human data (ACGIH (2001)), and was seen in the range of the guidance value of Cateory 2 by animal studies. So it was set as Category 2, and it is classified into Category 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - The dynamic viscosity at 20 degree C is 0.838mm [2/sec] (calculatd value). Since we have no animal data of chemical pneumonia, we could not classify it.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96-hour LC50=100000microg/L of fishes (Bluegill) (MOE Risk Assessment No.1, 2002).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since rapidly degrading (BOD: 98% (IUCLID, 2000)), and less bio-accumulative (log Kow=1.78 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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