GHS Classification Result

Chemical Name:1-methylethyl acetate
CAS:108-21-4

Result:
ID: 730
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
It was classified as Category 2 (GHS acceptance criteria: flash point being less than 23 degC, and initial boiling point being more than 35 degC) for 2 degC of flash point and 88.5 degC of initial boiling point.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 460degC (ICSC, 1998)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Category 5 based on SPECIES: Rat; ENDPOINT: LD50;VALUE:3000 mg/kg; REFERENCE SOURCE: ACGIH (7th, 2003)
1 Acute toxicity (Dermal) Not classified - - - - Based on rabbit dermal LD50 = 20mL/kg or more (RTECS (2005)) and 20000mg/kg or more (IUCLID (2000)), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Since 1 out of 6 rats died with 16000ppm, and 5 out of 6 rats died with 32000ppm (ACGIH (7th, 2003)). It was thought that LC50 by inhalation of vapor was larger than 16000 ppm, and it was classified as out of Category.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
There are statements that there is a possibility of becoming a cause of dryness, rednesses, cracks, and "severe" chemical burn on humans (ACGIH (2003), ICSC (1998), HSFS (2004)). But according to the result of Draize examination (skin application of 500mg) on rabbit, it was "mild" (ACGIH (7th, 2003)). And since it was thought that there was no irreversible disorder, it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
There is a statement that stimulativeness of the eye is carried out in humans and it can become a cause of redness or a chemical burn (PATTY and (5th, 2001), ICSC (1998), HSFS (2004), and SITTIG (47th, 2002)), and The Draize method test result in rabbit is "mild reaction" (ACGIH (7th, 2003)). On the other hand, there is a statement that the condition of an eye is recovered for a short times (PATTY (5th, 2001), GESTIS (2005)). It was set as Category 2B based on these information.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Since there was no information other than the negative result (IUCLID (2000)) of an in vitro mutagenicity test (reverse mutation test using bacteria), we presupposed that we could not categorize it according to the technical guideline.
6 Carcinogenicity Classification not possible - - - - Although there is data of rat and mouse, an administration period is unknown. Therefore, it cannot be classified since data is insufficient.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
A statement that there is respiratory irritation in humans (ACGIH(2003), HSFS (2004)) and a statement that a central nervous systems is affected (ICSC (1998), HSFS (2004), SITTIG (47th, 2002)). So it is classified into Category 2 (central nervous system) and 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified into Category 2 (respiratory system, liver) based on the statement that there is a risk of doing a damage to respiratory systems and liver in humans (HSFS (2004), SITTIG (47th, 2002)) .
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
We classified it as Category 2 based on the statement that there is a risk of chemical pneumonia in case of swalloed by aspiration into the lungs (ICSC (1998)), and the statement that of risk of chemical pneumonia by intake (SITTIG (47th, 2002)). Since it was unknown whether it is the description based on human case, We did not classify it as Category 1.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour LC50=110000microg/L of Crustacea (Brine shrimp) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (aqueous solubility =30900 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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