GHS Classification Result

Chemical Name：Pentyl acetate
CAS：628-63-7

Result：
ID: 732
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: 32degC (Hommel, 1991).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG No. 1104, Class: 3, PGIII
9 Pyrophoric liquids Not classified - - - - By the description, the ignition points is 375 degC (Hommmel (1991)), and it is over 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG No. 1104, Class: 3, PGIII

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Rat male: LD50>14000 mg/kg, rat female:LD50>12000 mg/kg (DFGOTvol.11 (1996)). Guessed from 64.8% of content of this product, it became more than 9072 mg/kg and more than 7776 mg/kg respectively, and it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Rabbit male: LD50 = 8300mg/kg, female: LD50 >14000mg/kg (DFGOTvol.11 (1996)). When guessed from 64.8% of content of this product, it became about 5378mg/kg and 9072mg/kg or more, respectively, and it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - LC50 (6h) >3600 - 3700ml/m3, i.e., LC50 (4h) >4352 - 4409ml/m3, is obtained based on description "1 of 10 rats died with 6 hour exposure to 3600 - 3700 ml/m3" (DFGOTvol.11, (1996)). Although which applied gaseous classification, Category could not be specified.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - No death by 5200ppm = 27.7mg/L of 4-hour exposure with six rats (DFGOTvol.11, (1996)). Therefore, since LC50 >27.7mg/L and any example of mortality was not acknowledged, it was set as the outside of Category.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. The isomer mixture was classified as Category 3 based on the observation of two rabbit skin irritation tests (the isomer mixture used as the test substance): "slight stimulativeness" and "moderate erythema, slight dropsy, and slight scaling seven days after application" (DFGOTvol.11 (1996)). In addition, there is discription that "disappearance by volatilization of the remarkable rate of a study substance could be considered at the time of application" for the examination where repetitive application of the isomer mixture on human skin. And 197 subjects did not observe irritation at all (DFGOTvol.11 (1996)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There are corneal injury in eye of rabbit, but it was mild and reversible, and the result of having applied the isomer mixture to the eye of the rabbit were also mild (2nd of ten steps of stimulative scales) (ACGIH (2001)). Although effect on the eye of isomer mixture postexposure is also reported in humans (ACGIH (2001)), it is adapted by long run challenge. As mentioned above, since it was thought that irritating is slight, it was referred to as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since the result of the guinea pig maximization test, which used as its test substance the isomer mixture 60% of which consisted of this product, stated that "sensitizing potential of the test substance is at most slight," (DFGOTvol.11 (1996)).it was put outside of the Category. In addition, although there is a statement on a test which applied an isomer mixture to the human skin, saying "Volatilization may have caused a considerable amount of loss of the test substance during its application, " there is a fact that sensitization was not identified in any of all 197 subjects (DFGOTvol.11 (1996)).
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - Since the presence of effects on reproductive functions or reproductive potential caused by exposure before pregnancy (premating) was not clear, it was referred to as "unclassifiable". In addition, in rat or rabbit organogenetic period administration test, it is observed of decrease weight gains of parent and decrease fetal weight and fetal delayed ossification in high-dose rat, but adverse developmental effects to offsprings as teratogenecity etc. is not observed in each species(DFGOTvol.11 (1996)).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the inhalation exposure examination in humans, condition such as "nasal irritation" and "throat irritation" is seen immediately after (DFGOTvol.11 (1996)), and the consciousness may fall by high concentrations (ICSC (2000)). Moreover, the anesthetic actions is observed in inhalation exposure of the rat (ACGIH (2000)). So it is classified into Category 3 (respiratory irritation, anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There is a statement that visual field constriction is reported by part of humans who received occupation exposure of the isomer mixtures (DFGOT vol.11 (1996)) and also neurotoxicity is occurred (PATTY (5th, 2001)). Moreover, the histologically degeneration of the optic nerve is acknowledged in repeated exposure to the rabbit (DFGOTvol.11, (1996)). It wasclassified into Category 1 (nervous systems) according to these knowledge.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data on an animal experimentation (chemical pneumonia, etc.), though Dynamic viscosity: <=14 mm2/s.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 24-hour LC50=53000microg/L of Crustacea (Brine shrimp)(AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (it hydrolyzed and acetic acid and pentanol are generated), and supposed less bio-accumulative (log Kow=2.3 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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