GHS Classification Result

Chemical Name:isopentyl acetate
CAS:123-92-2

Result:
ID: 734
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: 33degC (closed cup) (Merk, 13th, 2001) or 23degC(Chapman, 2005)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG No. 1104, Class: 3, PGIII
9 Pyrophoric liquids Not classified - - - - By the description, the ignition points is 360/379 degC (Chapman (2005)), and it is over 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG No. 1104 Class: 3, PGIII

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: 16600 mg/kg REFERENCE SOURCE: RTECS (2004)
1 Acute toxicity (Dermal) Not classified - - - - Based on rabbit LD50 >5000mg/kg (RTECS (2004)), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 based on the evaluation of "slight irritation" in the rabbit skin irritation test (isomer mixture as test substance) (DFGOTvol.11 (1996)). In addition, there is a description that "Disappearance of the test substance of a remarkable rate can be because of volatile at the time of application" on repetitive application test of this substance on human skin. And 197 subjects did not observe irritation at all (DFGOTvol.11 (1996)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
The result of an eye irritation examination of the rabbit which used the isomer mixture as the test substance is mild (2nd of ten steps of stimulative scales) (ACGIH (2001)), and this substance or an isomer mixture by inhalation exposure irritation is reported to the eye or the conjunctiva in humans (ACGIH (2001), DFGOTvol.11 (1996)). It was referred to as Category 2B based on these facts.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since the result of the guinea pig maximization test which used as the test substance an isomer mixture 5% of which consisted of this product states, "the sensitizing potential of the test substance is at most slight"(DFGOTvol.11 (1996)) , it was put outside of the Category. In addition, although it is mentioned in a test in which this substance was applied to the human skin, "It is considered that volatilization caused a remarkable disappearance of the test substance,"sensitization was not identified in any of the 197 test subjects. subjects.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
By this product or inhalation of a isomer mixture exposure, in humans, the upper respiratory conditions, such as nose, pharynx, respiratory tract, etc. is mainly reported (DFGOTvol.11 (1996), HSDB (2003)), and there is also description (DFGOTvol.11 (1996)) that it have strong irritation especially an respiratory tract (DFGOTvol.11 (1996)), and respiratory irritation was suggested. Furthermore, the anesthetic actions was observed in rat (ACGIH (2001)), and moderate central nerve inhibition in cat (HSDB (2005)), and drowsiness in dog (HSDB (2005)) was reported. So it is classified into Category 3 (respiratory irritation, anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
There is a statement that visual field constriction is reported by part of humans who received occupation exposure of the isomer mixtures (DFGOT vol.11 (1996)) and also neurotoxicity is occurred (PATTY (5th, 2001)). Moreover, the histologically degeneration of the optic nerve is acknowledged in repeated exposure to the rabbit (DFGOTvol.11, (1996)). It wasclassified into Category 1 (nervous systems) according to these knowledge.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data on an animal experimentation (chemical pneumonia, etc.), though Dynamic viscosity: <=14 mm2/s.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 24-hour EC50=205mg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (aqueous solubility=2000 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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