GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Subtilisins, as crystalline active enzyme
CAS：1395-21-7
Result：
| ID: | 736 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | No data available |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (room temperature) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (room temperature) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (room temperature) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (room temperature) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | No data available |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (room temperature) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible | - | - | - | - | No data available |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (room temperature) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available |
| 15 | Organic peroxides | Classification not possible | - | - | - | - | No data available |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Insufficient data available |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | Insufficient data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (room temperature) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Insufficient data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Insufficient data available |
| 2 | Skin corrosion/irritation | Category 2-3 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Irritation on human skin is reported. But there is no information on the extent (ACGIH, 2001). Therefore, it was classified as Category 2-3. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
It was set as Category 2A based on what severe eye irritations is reported by Draise test of the rabbit (RTECS, 2004). |
| 4 | Respiratory sensitization | Category 1 |
|
Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Human skin sensitization (identified in a skin patch test) and respiratory sensitization (such as airway obstruction, bronchus contraction, the fall of the amount of breathing and asthma) have been reported (ACGIH, 2001). Therefore, both skin sensitization sensitization and respiratory sensitization were referred to as Category 1. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Human skin sensitization (identified in a skin patch test) and respiratory sensitization (such as airway obstruction, bronchus contraction, the fall of the amount of breathing and asthma) have been reported (ACGIH, 2001). Therefore, both skin sensitization sensitization and respiratory sensitization were referred to as Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system) |
|
Danger | H370: Causes damage to organs (respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Pulmonary edemas are acknowledged by guinea pigs inhalation exposures (ACGIH, 2001), and this exposure concentrations is set as category 1 as compared with a guidance value. Moreover, it is classified into Category 1 (respiratory systems) based on respiratory irritation being reported in humans (ACGIH, 2001). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |