GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Titanium dioxide
CAS：13463-67-7
Result：
| ID: | 740 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not classified because of "Not combustible" (HSDB (2005)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not classified because of "Non-combustible" (HSDB, 2005) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not classified because of non-combustible (HSDB, 2005) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not classified | - | - | - | - | Stable oxidizing substance |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic substance |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | SPECIES: Rat ENDPOINT: LD50 VALUE: > 10000 mg/kg REFERENCE SOURCE: IUCLID (2000) |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | It was set as the outside of Category from the description of rabbit approx.LD >10000mg/kg (IUCLID (2000)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not classified | - | - | - | - | Not classified because of "SPECIES: Rat; LC>6.82mg/L/4h" (IUCLID, 2000) |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | It was classified as out of Category from the statement of slightly irritating, and not irritating in rabbit examination (IUCLID (2000)). |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
It was set as Category 2B from the statement with mild by rabbit test (IUCLID (2000)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Since there is no data, it cannot be classified. |
| 4 | Skin sensitization | Not classified | - | - | - | - | It was put outside of the Category because of the negative publication of a patch test.in humans(IUCLID (2000)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | We classified it as Out Of Category based on the description that it gave negative for the mouse micronucleus assay, and negative for the mouse chromosomal aberration test (NTPDB (2005)). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | It carried out the outside of Category from it being classified into a group 3 according to IARC, and being classified into A4 according to ACGIH. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Hume was set as category 3 (respiratory irritation) from the statement which stimulates an respiratory tract (HSDB (2005)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (Inhalation: lung) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (Inhalation: lung) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified into Category 1 (lungs: inhalation) according to the statement that pneumoconiosis changes became clear by x-ray test, although not accompanied by change of the lung function of very few of the laborers with occupational exposure for 20 years or more (DFGOTvol.2 (1991)) . |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Since it was suggested from 48-hour EC50>1000000microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003), and others that relevant toxicity is not indicated in the water solubility (insoluble (HSDB, 2004)) of this substance, it carried out the outside of Category. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 4 | - | - | H413: May cause long lasting harmful effects to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 4, since it is a metallic compound, and behavior in water is unknown, though no acute toxicity is reported within the saturated aqueous solution. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |