GHS Classification Result

Chemical Name：Cyanamide
CAS：420-04-2

Result：
ID: 749
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point of liquid articles: none
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data on liquid articles, though the substance contains aminonitrile groups as chemical groups with self-reactive properties present.
9 Pyrophoric liquids Not classified - - - - A liquid product is not flammable nor ignitability.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Since the liquid (liquid product) examining method hass not been established, it cannot be classified.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - No data available on corrosion to metals

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 （Active ingredient） Danger H301: Toxic if swallowed (Active ingredient) P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is in Category 5, because it is over LD50= 2415mg/kg (Agricultural-Chemicals abstracts (2002)) in the male rat examination, and this is over 2000mg/kg (Category 4). Moreover, it is thought that a pure forms (active ingredient) is in Category 3 by being estimated from this value.
1 Acute toxicity （Dermal） Classification not possible （Active ingredient） - - - - Death is not observed at 2000mg/kg (Category 4)(Agricultural-Chemicals abstracts (2002)) using rats, it is outside of Category. Since death is not seen and it cannot be estimated, an active ingredient cannot be classified.
1 Acute toxicity （Inhalation: Gases） Classification not possible （Active ingredient） - - - - Solutions is outside of classification since it is the liquid based on GHS definition. Since there is no data about active ingredient, it cannot be classified.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There is a rat dust inhalation test result (Agricultural-Chemicals abstracts (2002)), that contains 57% of calcium cyanamide. And it is not a test result of cyanamide active ingredient, it cannot be classified.
2 Skin corrosion/irritation Not classified （about 10% liquid products） - - - - Based on the test result of rabbit examination (solution with 13.33% purity), irritation was not observed(Agricultural-Chemicals abstracts (2002)), and it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified （about 10% liquid products） - - - - It was carried out the outside of Category by the report that cyanamide 13.33% solution was judged not to indicate irritation to eye of rabbit (Agricultural-Chemicals abstracts (2002)).
4 Respiratory sensitization Classification not possible - - - - Since there is no information on respiratory sensitization, it cannot be classified.
4 Skin sensitization Category 1 （about 10% liquid products） Warning H317: May cause an allergic skin reaction (about 10% liquid products) P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Skin sensitization was set to Category 1 because it was identified positive against the liquid solution of 13.34% in the test result with guinea pigs(Agricultural Chemicals abstracts (2002)).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was judged to have clastogenic activity for the in vivo test and mammals cultivation cells (Agrichemical Abstracts (2002)), therefore we classified it as Category 2.
6 Carcinogenicity Classification not possible - - - - Since there is no information of animal examination data and an evaluation organization, it cannot classify.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data on tests to reproduction and teratogenicity tests.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although the oral test result of a rat (Agricultural Chemicals abstracts (2002)) is available, since given dose etc. is unknown, it cannot be classified.
10 Aspiration hazard Classification not possible - - - - No data available on chemical pneumonia and a dynamic viscosity

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=33.5mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and rapid degradability is unknown, though supposed less bio-accumulative (log Kow=-0.82 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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