Chemical Name:2,2'-Iminodiethanol
CAS:111-42-2
ID: | 758 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Flash point: 280-662degC (Solvent Pocket Book, 1997; ICSC, 1994; NFPA,13th, 2002) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements). |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
It was set as Category 4 based on LD50= 1613mg/kg calculated by technological guidelines using 4 date of rat LD50 value (ACGIH (2001), PATTY (5th, 2001)). | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on rabbit LD50 = 8810.5mg/kg calculated by technological guidelines using three data of rabbit LD50 values, it was set as the outside of Category. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | The saturated vapor pressures concentrations pressure of this product is 0.37ppm. Mortality is not seen according to two rat acute toxicity tests (IUCLID (2000)) in saturated vapor pressure pressures concentrations. And LC50 level is not calculated, it cannot be classified. |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
Though the stimulative grades vary from severe to slight, skin irritation is observed on rabbits (ACGIH (2001) and PATTY (5th, 2001)). Since there is a description of slight to moderate irritations on human (HSDB (2005)), and it is classified into R38 in EU, it was classified as Category 2. | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Severe irritation is indicated by the rabbit (ACGIH (2001), PATTY (5th, 2001)). In humans, there is a statement that redness, a pain, severe burns and caustics are indicated (ICSC (J), (2002)), and it was classified into R41 in EU. So it was set as Category 1. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
4 | Skin sensitization | Not classified | - | - | - | - | Based on facts that in two examinations (one of them based on the guideline 406 of OECD test) with guinea pigs sensitization was not identified ACGIH (2001), IUCLID (2000)) and that in the human patch test no sensitization was identified(IUCLID (2000)), it was put outside of Category. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | There were no in vivo mutagenicity test results and there were no positive findings for in vitro tests in multiple indices. Therefore we presupposed that we could not classify it. |
6 | Carcinogenicity | Not classified | - | - | - | - | Based on what is classified into 3 according to IARC (IARC (2000)), it carried out the outside of Category. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Since although concrete reproductive toxicity is not observed in each animal studies, examination being clear of administration period are in organogenetic period administration, and there is no examination data in other administration period, it cannot be classified due to insufficient data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (liver), Category 3 (narcotic effects) |
Danger Warning |
H370: Causes damage to organs (liver) H336: May cause drowsiness or dizziness (narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
By oral administration test of rats, within the dose of guidance value of Category 1, an anesthetic actions (a sedative action, ataxia) and a liver damage (the increase in weight, the increase of serum transaminase and other liver enzyme, opacity swelling and vacuolar degeneration, damage of endoplasmic reticulum and mitochondria )was seen (ACGIH (2001)). So it is classified into Category 1 (liver) and Category 3 (anesthetic actions). | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney, blood, central nervous system) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, blood, central nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Liver and kidney weights gain and nephropathy are observed in the dosage of guidance value within the limits of Category 2 to a rat (PATTY and (5th, 2001),ACGIH (2001)), the data of anemia, such as decrease of red count, hemoglobin concentration, and hematocrit value, and demyelinate in brain and spine are observed (ACGIH (2001)), and affecting liver and kidney is observed in humans (ICSC (J), (2002)). It was classified into Category 2 (liver, the kidney, blood, central nervous system) according to the above information. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 48-hour LC50=2150microg/L of Crustacea (Water flea) (AQUIRE, 2003). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since rapidly degrading (the decomposition of TOC: 96.7% (Existing Chemicals Safety Check Data)), and supposed less bio-accumulative (log Kow=-1.43 (PHYSPROP Database, 2005)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |