GHS Classification Result

Chemical Name:Diethylamine
CAS:109-89-7

Result:
ID: 759
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: <-26degC, Boiling point: 55.5degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Not ignite spontaneously on coming into contact with air at normal temperatures
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Category 3 based on SPECIES: Rat; VALUE: 248mg/kg; REFERENCE SOURCE: ACGIH (2001), IUCLID (2000)
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since the calculation value using two or more data of the rabbit dermal acute toxicity values (IUCLID (2000)) is 582mg/kg, it is in Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Since the rat 4-hour inhalation acute toxicity value was 4040ppm (PATTY (2001)) and 5780ppm (IUCLID (2000)), adopting the lower data and classified it as Category 4.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
There are reports of corrosivity for many studies on rabbits. (IUCLID(2000))
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
In many animals studies report with irritant (IUCLID (2000)), but there is also a description with damage to a serious eye (ACGIH (2001)). Moreover, since corrosion of the skin / irritation is categoried into Category 1, critical damage / irritation over an eye are set as category 1.
4 Respiratory sensitization Classification not possible - - - - There is no data and it cannot be classified.
4 Skin sensitization Classification not possible - - - - Although there is a datum about skin sensitization describing that a Mouse ear swelling test did not identify it(IUCLID (2000)), this is not enough to put it outside of Category.
5 Germ cell mutagenicity Not classified - - - - In the in vivo examinations, such as the dominant lethality examination using the rat, the micronucleus assay, and the sex-linked recessive lethals examination using the drosophilas, the positive result was not obtained for diethylamine itself (ACGIH (2001)). Moreover, many negative results for in vitro examination (Ames test) were obtained (ACGIH (2001), IUCLID (2000)). Therefore we judged it as Out Of Category. However, diethylamine showed mutagenicity when administered simultaneously with nitrous acid (DFGOT vol.1 (1991)).
6 Carcinogenicity Not classified - - - - In the test using a guinea pigs, carcinogenic was not acknowledged, and it has been classified into A4 (ACGIH (2001)). So it carried out the outside of category. However, it is reported that diethylamine changes to nitrosamine in the internal (ACGIH (2001)).
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 2 (liver, respiratory system) Warning H371: May cause damage to organs (liver, respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
Starting corrosive to respiratory tract and pulmonary edemas in human is pointed out (ICSC (J) (1997)). Moreover, in short-term exposure in a rabbit, the influence of fatty liver degeneration, pulmonary edemas, emphysema, etc. is regarded (RTECS (2005)). So it is classified into Category 2 (target organ: liver, respiratory-organs system).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Effect was observed in lungs and the kidney in the inhalation study of 100 ppm for six weeks to a rabbit (ACGIH (2001)). This concentration is within the limits of the guidance value of Category 1 in 90-day conversion. Effect was observed at lesion of the respiratory system epithelium etc. in the inhalation study of 250 ppm for 24 weeks to the rat (ACGIH (2001)). This density is within the limits of the guidance value of Category 2. According to this point, Category 1, and target organ are the kidney and the respiratory systems.
10 Aspiration hazard Classification not possible - - - - We have a report of the case of pneumonia by the exposure in the accident (ACGIH (2001)), however, we could not classify it because not obvious of occuring by aspiration.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96-hour LC50=27mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1999).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since rapidly degrading (BOD: 89% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.58 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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