GHS Classification Result

Chemical Name：1,2-diethylhydrazine
CAS：1615-80-1

Result：
ID: 761
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - As the similar property to the N,N'-Diethylhydrazine's, Sym-Dimethylhydrazine: UNRTDG No. 2382, Class: 6.1, Subsidiary risks Class: 3, P, PG I (not Class: 1, explosives). N,N'-Diethylhydrazine is expected not to be explosives solely.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Although the flash point data was not found, it was stated "1,2-Diethylhydrazine may burn, but does not readily ignite." in HSFS (2001). Therefore, it was regarded as "out of Category".
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - They are not explosives although hydrazines structure is included. Since the name has not gone up to list of UNRTDG 2.4.2.3.2.3, there is no formal decisions that it is from class B to F. The information on SADT and heat of decomposition were not acquired, either. Although Class G was presumed, data was insufficient. So it was presupposed "It cannot be classified."
9 Pyrophoric liquids Not classified - - - - There is no information that it ignites spontaneously in the reliable collection of physical chemistry data. From the description in HSFS (2001) "1,2-Diethylhydrazine may burn, but does not readily ignite.", it was classified as "Outside Category".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of experimental data, though it is a redusing substance and expected that it does not corrode metals.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - There is no oral administration experimental data, so it cannot be classified. The single dose which exceeds 50mg/kg by intravenous injection to pregnant rat (150mg/kg: refer to carcinogenicity) is performed. HSDB (2003) has a statement that this is less than 33% of LD50. Therefore, infusion LD50 is considered as 450mg/kg or more, and it is presumed that oral acute lethal toxicities is also in the range of "from Category 4 to outside of Category" (probably Category 5).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Since there was no skin irritation experimental data, it "cannot be classified." Since there is a statement that irritation is caused by skin contacts (HSFS (2001)), it is supposed to be "Category 2" or "Category 3".
3 Serious eye damage/eye irritation Classification not possible - - - - Since the eye irritations experimental data was not able to be found out, it cannot be classified. Since there is a statement that an irritation is caused by eye contacts (HSFS (2001)), "Category 2A" or "Category 2B" is presumed.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - There were no in vivo test reports and we found only in vitro test report for Salmonella typhimurium mutant. Data was insufficient and we could not classify it.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it had classified into 2B in IARC and Japan Society for Occupational Health, it was set as "2." Although it is said that 1,2-diethyl hydrazine itself is not carcinogenic, it was shown that azoethane and azoxy ethanes as metabolites in internals are carcinogenic in rats.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The rat at 15 days from gestation was medicated and cancer (cranial nervous systems) was generated to child (IARC (4th.1974)). The effects on the embryo is also reported in the high-dose (RTECS (2000)). It was classified into "Category 2 " from these results.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - There is no laboratory reports and it cannot be classified. Since there is a statement tha the respiratory system which includes lungs stimulus by inhalation, and thrill and attack in high concentration exposure (HSFS (2001)), the "category 2 (inhalation, the respiratory system, nervous system)" can be considered.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - There is no laboratory reports and it cannot be classified. Since there is description that liver and the kidney are damaged in HSFS (2001), it is considered "Category 2 (liver, kidney)."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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