GHS Classification Result

Chemical Name：Cyclohexanol
CAS：108-93-0

Result：
ID: 763
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (room temperature)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 300degC (Chapman, 2005; etc.)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. SPECIES: Rat ENDPOINT: LD50 VALUE: 2.06 g/kg REFERENCE SOURCE: ACGIH (2001)
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LDLo value (IUCLID (2000); 12400 - 22700 mg/kg), LD50 value is guessed as 5000mg/kg or more.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Rat LC50 value >878ppm (IUCLID (2000)) was presupposed to be vapor test from saturation steam pressure (1049 - 1293ppm). But it cannot be classified since LC50 value was unspecified.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 based on the statement of "only slightly irritant to the rabbit skin" (ACGIH (2001) and Patty (5th, 2001)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since four in the four animals in the animal tests, the scores of Corneal opacity after 24, 48 or 72 hours are 3 respectively, and in which the one animal has not recovered from the disorder after 21 days (ECETOC TR48 (2), (1998)). So it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although a result of human patch test of skin sensitization is shown in Patty (5th, 2001), since its details are unknown, it cannot be classified.
5 Germ cell mutagenicity Not classified - - - - Based on the negative result in a somatic cell in vivo mutagenicity test (micronucleus examination), we classified it as Out Of Category according to the technical guideline.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since although the bad influence (the increase in mortality rate and growth inhibition of child) to future-generations was observed in the mouse studies, effect on parent animals were unknown (ACGIH (2001)), it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since respiratory irritation (Patty (5th, 2001)) and anaesthetic (ACGIH, 2001) were seen, respectively, it is classified into Category 3 (respiratory irritation, anaesthetic).
9 Specific target organ toxicity - Repeated exposure Category 1 (autonomic nervous system), Category 2 (liver, kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (autonomic nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified into Category 1 (autonomic nervous systems) according to that (ACGIH, 2001) autonomic nervous disorders was seen in humans. Moreover, since slight degeneration in liver and kidney were observed in the dosage of a guidance value of Category 2, it was classified into Category 2 (liver, kidney).
10 Aspiration hazard Not classified - - - - Not classified because of the dynamic viscosity: 24.6 mm2/s at 40oC.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50=704mg/L of fishes (Fathead minnows) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =42000 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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