GHS Classification Result

Chemical Name：Cyclohexanone
CAS：108-94-1

Result：
ID: 764
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: 43degC (Hommel, 1991).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG No.2915, Class: 3, PGIII
9 Pyrophoric liquids Not classified - - - - Flash point: 420degC (Hommel, 1991)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Not classified - - - - Not classified because of UNRTDG No.1915, Class: 3, PG III

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Category 4 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: VALUE:1544mg/kg;
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 from rabbit LD50= 947mg/kg (DFGOT, 1998-ATTY, 2001).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on Saturated vapor pressure concentration = 5700ppm (25degC) (Howard, 1997), rat LC50 = 2450ppm (ACGIH, 2003) was judged to be steam exposure value, and it was classified as Category 3.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on saturated vapor pressure pressures concentrations = 5700ppm (25degC) (Howard, 1997), rat LC50 = 8000ppm = 32.1mg/L (the collection of CERI data, 2000) was judged as the value by mist exposure and set as the outside of Category.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 based on the description "there is moderate stimulativeness" in CERI Hazard Data (2000).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the statement of "the human eye irritations"(PATTY (5th, 2001) and "the severe irritations in the eye of a rabbit"(CERI Hazard Data (2000), it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Although a case of one human is reported (IARC (Vol71, 1999), ACGIH (2003)), since sensitization has not been identified in animals it was put outside of the Category.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it gave negative in the dominant lethality examination and positive in the bone marrow cells chromosomal aberration test in the rat (both of them were in CERI Hazard Data(2000)), we classified it as Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		IARC classifies into 3 (1999) and ACGIH classifies into A3 (2003). It was set to category 2 based on the classification of ACGIH which time of assessment is the latest.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In any reports, reproductive toxicity is not reported and it is indicated that there is no teratogenicity in any case. However, in high concentration of exposure, adverse effect of child under indecement of the adverse effect to maternal is reported(ACGIH(2003);DFGOTvol.10 (1998)). Therefore, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (liver, spleen, central nervous system), Category 2 (lung), Category 3 (narcotic effects, respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (liver, spleen, central nervous system)
H371: May cause damage to organs (lung)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		The effects on the liver is reported by humans (DFGOT, vol.10, 1998), it was set to Category 1 (liver). by that which . Spleen effects in rat (4250ppm = 19mg/L) (PATTY, 5th, 2001) was compared with the guidance value, and set to Category 1 (spleen). Moreover, the influence on a central nervous systems (mouse (ACGIH, 2003)) is estimated by a guidance value, and it was se to Category 1 (central nervous system). And the influence on lungs (mouse (ACGIH, 2003)) was set as Category 2 (lungs). Moreover, there is the statement that anesthesia influence in an animal (ACGIH, 2003; PATTY, 5th, 2001; DFGOT, vol10, 1998)) and human respiratory irritation (ACGIH, 2003), it is classified into Category 3 (an anesthetic actions, respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, liver, central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney, liver, central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified into Category 1 (the kidney, liver, central nervous system) according to that effects to the kidney, liver, central nervous system is observed in humans (PATTY5th, 2001).
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In this surver, no data of the aspiration breathing apparatus hazards, however, the dynamic viscosity is considered to be (40 degrees C) <14mm2/s (dynamic viscosity = 2.13mm 2/s (24 degrees C) (based on Renzo (3rd, 1986))), moreover, "there were also the authorities which classified the ketone of 13 or less carbon atoms," therefore we classified it as Category 2.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50=527mg/L of fishes (Fathead minnows), and others (CERI Hazard Data, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =25000 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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