GHS Classification Result

Chemical Name：Ethane, 1,1-dichloro-
CAS：75-34-3

Result：
ID: 772
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		It was classified as Category 2 (GHS standards: flash point being less than 23 degC, and initial boiling point being more than 35 degC) based on flash point -17 to -5.6 degC and initial boiling point 57 to 59 degC .
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 458degC (ICSC, 1993; NFPA (13th, 2002); Hommel, 1991)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although the statement of corroding aluminum and iron (ICSC (1993)), since there is no detailed test data, it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Not classified because of SPECIES: Rat; ENDPOINT: LD50; VALUE: 14.1 g/kg; REFERENCE SOURCE: PATTY(5th, 2001)
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on LC50 = 52.5mg/L calculated from rat LC50 = 13000 ppm (equivalent value: 52.5 mg/L) (ACGIH (7th, 2001), PATTY (5th, 2001)), and rat LC50 = 16000ppm (equivalent value: 91.4 mg/L) (HSDB (2005)), it was classified as Category 5. In addition, the saturated concentration of this product is 3.0*10^5ppm, and it is presumed that the inhalation test is done in the state of steam.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Although there are descriptions that dryness and roughness due to degreasing of the skin take place with the long-term and repetitive exposure of this product (ICSC (J) (1993)), it does not indicate direct skin irritation. There is no concrete data on skin irritation, it cannot be classified because of data insufficiency.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There was description that R36/37 which indicate eye stimulation are applied in European risk phrases. If eye of rabbit is medicated, the moderate irritation of the conjunctival, and a partial swelling will take place immediately (it returns to normal within one week) (IUCLID (2000), "a human eye is stimulated" (ACGIH (7th, 2001), PATTY (5th, 2001), and "redness and pains (ICSC (J), (1993)". So it was set as Category 2A-2B. [Indications] in the case that subdividing are necessary, it is more desirable to be set as Category 2A from the viewpoint of safety.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - It gave positive finding by the in vivo DNA junction examination using rats and mice (ACGIH (7th, 2001); ATSDR (1990)), however, it gave negative in the chromosomal aberration test of the in vitro mutagenicity test. And although in some cases it gave negative in the Ames test, it gave generally negative. Therefore we presupposed that we could not categorize it according to the guideline of the classification.
6 Carcinogenicity Not classified - - - - It was categorized into A4 according to ACGIH (7th, 2001), and into C according to EPA (1996). So it carried out the outside of category according to classification guidelines.
7 Reproductive toxicity Not classified - - - - It was considered as out of category based on that in rat inhalation tests, in both mother and child, although it was small, except for the significant decrease feed intake cunsumption and effects to delayed ossification were not observed and teratogenicity also was not observed (ACGIH (7th, 2001), ATSDR (1990), PATTY (5th, 2001)).
8 Specific target organ toxicity - Single exposure Category 1 (liver, kidney), Category 3 (narcotic effects, respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (liver, kidney)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In Priority 1, there is description that there is an anesthetic actions to humans, the influence on the liver and the kidney and respiratory irritation are seen (ACGIH (7th, 2001), PATTY (5th, 2001), ATSDR (1990)), so it is classified into Category 1 (liver, kidney) and Category 3 (an anesthetic actions, respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified into Category 2 (kidney, liver) from description of Priority 2 (ICSC (J), (1993), SITTIG (4th, 2002)) that the human kidney and liver may be affected. In addition, although effects on the central nervous systems,renal, and the liver were seen in the animal experiments, all were the results in the amount which exceeds the guidance value range of Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 24-hour TLm=320mg/L of Crustacea (Brine shrimp) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =5040 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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