GHS Classification Result

Chemical Name:2,2-Dichloropropionic acid
CAS:75-99-0

Result:
ID: 779
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules. (As a sodium salt, the substance was authorized for the agricultural chemicals registration (herbicide) in the country and examined in this GHS classification. The sodium salt has the CAS number: 127-20-8, the molecular formula: C3H3Cl2NaO2, molecular weight: 164.95, and the properties of a free body: liquid.)
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of experimental data, though "Flammable solid" (BGIA GESTIS-database on hazardous substances, Accessed in 2006)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Not classified - - - - Since there is the description that "in the usual state, it is stability" in agricultural-chemicals applications for registration data (1999), and that "are stabilized at less than 150 degC"in PM (13th, 2003), it was judged as the outside of Category.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and the chlorine is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Corrosive to Iron (Merck, 13th, 2001)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - From male and female LD50 value of the oral administration study using rats: >5000mg/kg (Agricultural Chemical Registration Data (1999)), it was set as the outside of Category. [Note] The domestic pesticide registration (herbicide) is authorized as sodium salts of this product. In this GHS classifications, all were investigated as sodium salts. For sodium salts, CAS number is 127-20-8, the formula are C3H3Cl2NaO2, and the molecular weights is 164.95. In addition, the quality of the Free body is a liquid.
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. From LD50 value of the dermal administration test using a rat for male and females: >2000mg/kg (Agricultural Chemical Registration Data (1999)), it was set as Category 5.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Since rat LC50 value of the inhalation exposure test (dust mists) is indicated male and females: >4.15mg/L/4H (100% purity equivalent: >1.25mg/L/4H))(Agricultural Chemical Registration Data (1999)), it was set as Category 4.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Although reversible stimulus (erythema and dropsy with Draize score 4) was observed in the skin irritation test on rabbits, these symptoms disappeared in 48 hours (Agricultural Chemical Registration Data (1999)). Therefore, it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Although in the eye irritation tests using a rabbit the reversible irritation (mild corneal cloudings, conjunctival redness, and swelling) was observed, the symptom disappeared in 72 hours (Agricultural Chemical Registration Data (in 1999). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since it was negative for the guinea pig in Maximization method (Source: Agricultural Chemical Registration Data (1999)), we classified it to be out of Category.
5 Germ cell mutagenicity Classification not possible - - - - Since the in vivo mutagenicity test has not been carried out, we presupposed that we could not classify it since data was insufficient. In addition, it gave negative for the in vitro mutagenicity test (reverse mutation test, chromosomal aberration test) (Agricultural Chemical Registration Data (1999)).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - It cannot be classified due to insufficient data since in the teratogenicity study using rats and rabbit, although neither of teratogenicity was indicated (Agricultural Chemical Registration Data (1999)), the evaluate to fertility property was not made.
8 Specific target organ toxicity - Single exposure Not classified - - - - In the rats oral acute toxicity studies (0, 2500, 5000mg/kg) (Agricultural Chemical Registration Data (1999)), deaths was not seen and the symptom which should be mentioned specially was not acknowledged, so it is classified as the out of the Category.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Since the maximal no-effect dose is 1000 ppm (70 to 80 mg/kg/day) in the subacute toxicity study for three months of a rat (Agricultural Chemical Registration Data (1999)), and the observationg at the highest dose of 5000 ppm (350 to 400 mg/kg/day) was that the particular abnormality was not seen in histopathological examination except for the slight inhibition of increase in weight and increase in kidney weight of a female rat, it was classified the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour EC50>=200mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (aqueous solubility =5.02*105mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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