GHS Classification Result

Chemical Name：2,6-Di-tert-butyl-p-cresol
CAS：128-37-0

Result：
ID: 784
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although there is a report of 127 degC of flash point (ICSC (1999)), since there is no data from tests of United Nations, it cannot be classified.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 345degC (GESTIS, 2006) and non-pyrophoric at a room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not halogen) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		There are many reports and rat LD50: 1559 mg/kg calculated by statistical calculations. From this value, it was set as Category 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 from rat LD50 >2000mg/kg (SIDS (2002)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. A blockade application is done on rabbits and of slight irritation (CERI Hazard Data (1997)), and there are statements of slight irritation (SIDS (200)), and of slight irritation to humans (SIDS (2002)), therefore it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		By the statement of that in the rabbit test mild inflammations in the conjunctival were seen, and recovered 72 hours afterward (CERI Hazard Data), it was set as Category 2B.
4 Respiratory sensitization Not classified - - - - We categorized it to be out of Category taking the enrolment of (IUCLID (2000)) as the basis, in which no anaphylaxis was found for the allergic shocking examination of the guinea pig.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		We categorized it as Category 1 since we found an enrollment that sensitizing property was acknowledged by humans (CERI Hazard Data (1997), SIDS (2002), ACGIH (2001)),although there are negative reports (CERI Hazard Data (1997), SIDS (2002), IUCLID (2000)) in test with guinea pigs.
5 Germ cell mutagenicity Not classified - - - - Based on the statement that it gave negative for all of the in vivo reciprocal translocation examination of the mouse, the dominant lethality examination of the mouse, the specific locus examination of the mouse, the micronucleus examination of the mouse, and the chromosomal aberration test of mouse and rats (SIDS (2002)), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Since the classification of ACGIH set to A4 and AIRC considered it as group 3, it was set the outside of category.
7 Reproductive toxicity Not classified - - - - In the two-generation feeding administration test, weight gains and effects on kidney in the high-dose group(F0) and suppression of weight gains in (F1) group were observed (Collection of CERI Hazard Data(1997)). Reproductive and developmental toxicity was not observed in the three-generation feeding administration test (SIDS (2002)). There are two reports (SIDS (2002) and another report (IARC (1986), both stating that administration to pregnant rats did not show any reproductive toxicity. Moreover, there is a report of anophthalmia in one offspring (IARC (1986)) and microphthalmia in three offsprings /30 mothers (IARC (1986)) were observed in long-term administration test. However, since there is a report that no anophthalmia was observed (IARC (1986)) and the distribution of the three examples of microphthalmia is not clear, any of those reports is not employed by IARC for its inadequacy. Suppression of weight gain was observed in the high dose group, and suggests that it was caused by general toxicity. Based on the above-mentioned, it was judged to be out of classification.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		By the woman who ingested 4g, stomach cramps, a feeling of worthlessness, vomiting, a feeling of fatigue, mental disorder, and a short term of unconsciousness was seen. Moreover, it is classified into Category 1 (nervous systems) according to the the statement as which nervous symptoms are regarded in woman who took in 80g lysed in safflower oil (CERI Hazard Data (1997), ACGIH (2001), SIDS (2002)).
9 Specific target organ toxicity - Repeated exposure Category 2 (lung, liver, thyroid) Warning H373: May cause damage to organs through prolonged or repeated exposure (lung, liver, thyroid) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There was no report about humans. In the study of feeding administration to a mouse, with the given dose within the guidance value of Category 2, the congestion and enlargement of lungs, and a necrosis and degeneration of alveolar epithelial cell were acknowledged (SIDS (2002)), in the oral administration study of a rat with the given dose within the guidance value of Category 2, increase in relative weights of liver, hepatic periportal necrosis and enlarged hepatic cell were observed (collection of CERI hazard data (1997)), in the feeding administration study of a rat, within the guidance value of Category 2, the enlargement of the liver, necrosis of centrilobular hepatocyte, depletion of glutathione, the increase in transaminase activities, enzyme induction, increase in phospholipid and cholesterol, and the enlargement of the thyroid glant accompanying increased iodine uptake were observed (collection of CERI hazard data (1997)). It classified into Category 2 (lungs, liver, thyroid gland) since the above result.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=0.84mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1999).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 4.5% (existing chemical substances safety inspections data)), and bioaccumulative ((BCF=2800 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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