Chemical Name：methyl 2-[[[[(4,6-dimethyl-2-pyrimidinyl)amino]carbonyl]amino]sulphonyl]benzoate
CAS：74222-97-2

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the description (ACGIH (2001)) of "there is no death of male and female rats after 5000 mg/kg of oral administration", it was set as the outside of Category.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the description that "There is no death after dermal administration of 2000mg/kg to male and female rabbits"(ACGIH (2001)), it was set as the outside of Category.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on description that "there is no death in male and female rats after 4-hour inhalation exposure of 11000mg/m3" (ACGIH (2001)), it was set as the outside of Category. (11000mg/m3 = 11mg/L)
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	In the skin irritation test on rabbits, "Slight irritation (1.3 - 2.9 on a scale of 5 for primary irritation)", and in the test on guinea pigs, it was estimated to have "Mild skin irritation" (ACGIH (2001)). Therefore, it was classified as Category 2.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	There is the description that although in the two tests applied to the eyes of the rabbits, mild conjunctivitis or mild corneal cloudings were started respectively, they were recovered within two days or four days, respectively (ACGIH (2001)). So it was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Not classified	-	-	-	-	Based on the estimation as "No sensitization" (ACGIH (2001)) about the test using guinea pigs, we classified it as Out Of Category.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data
6	Carcinogenicity	Not classified	-	-	-	-	Based on being classified into A4 (1994) according to ACGIH, it carried out the outside of Category. Additionally, in the carcinogenicity test by the mix feed medication using rats and mice, the increase in tumorigenic frequency is not admitted for both kinds of animals.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It was classified into Category 2 since decrease in litter size of hygh dose group compared with of the control group in the two-generation reproduction test of rat (ACGIH (2001)) and there was no descriptions about the general toxicity in parent animal.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Not classified	-	-	-	-	Affect to the blood systems is acknowledged in a rat, mice and dogs in several studies which carried out repetitive exposure for two week-two years (ACGIH (2001)), however, since all were beyond guidance values, the expressed dose made them the outside of Category.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 14 days EC50=0.48ppb of aquatic plant (Lemna gibba) (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.2(PHYSPROP Database, 2005)).