GHS Classification Result

Chemical Name：Zirconium dichloride oxide
CAS：7699-43-6

Result：
ID: 809
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-flammable (Weiss (2nd, 1985))
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not classified because of "Non-flammable" (Weiss (2nd, 1985)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of non-flammable (Weiss, 2nd, 1985)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Not react with water. (Weiss, 2nd, 1985)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. SPECIES: Rat ENDPOINT: LD50 VALUE: 3500 mg/kg REFERENCE SOURCE: DFGOT vol.12 (1999)
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Skin sensitization was negative (DFGOT vol.12 (1999)) in both examinations of modified Magnusson and Kligman test using guinea pigs and lymph node assay using the mouse, moreover, there was no onset of the symptoms which suggests skin sensitization by the test using human volunteers (ACGIH (2001)), therefore we classified it as Out Of Category.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the chromosome aberration test (somatic cell in vivo mutagenicity test) using the marrow cells of the mouse, it was classified as Category 2 based on the reported significant increase in chromosome aberration (PATTY (5th, 2001), DFGOT vol.12 (1999)).
6 Carcinogenicity Not classified - - - - Since it was classified into A4 according to ACGIH (1996) as zirconium and zirconium compound, it was considered as the outside of Category.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, digestive system, liver, blood, urinary system, circulatory system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (nervous system, digestive system, liver, blood, urinary system, circulatory system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		As acute intoxication by oral ingestions in humans, there are descriptions about symptoms relevant to a wide range of organs, including digestive organs, liver, blood, urinary system, nervous system and circulatory system (PATTY (5th, 2001)). Among these symptoms, development of convulsion and gastrointestinal hemorrhage is reported as a serious toxic effect in animals (RTECS (2004)). Therefore we classified it into Category 1 (nervous system, gastrointestinal system, liver, blood, urinary system, circulatory system). In addition, there is description that "an airway can be stimulated in the process of hydrolysis to hydrochloric acids" (PATTY (5th, 2001)). Therefore we classified it as Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour LC50=15000microg/L of fishes (Bluegill) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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