NITE - Chemical Management Field

GHS Classification Result

Chemical Name：temephos
CAS：3383-96-8

Result：


ID:	826
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	It is a solid by the definition of GHS. However, since this product is liquefied at 30 - 31 degC, and the flash point is 43 - 93 degC and it is equivalent to the flammable liquid of "Category 3" or "Category 4" depending on storage conditions, precautions are required.
7	Flammable solids	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though "Flammble" (ICSC(J), 1995; etc.)
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-reactive properties present.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Although there was no data of firing point, it was judged that there was no spontaneous combustibility at normal temperature since the flash point was measured at normal temperature or higher temperatures (HSDB (2005), Gangolli (2nd, 1999)).
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test suitable for a liquid state substance (solid with a melting point of 140degC or less) has not been established.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Since aqueous solubility is measured (ICSC (1995), Merck (13th, 2001), Howard (1997)), it can be judged that it is stable in the water.
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though containing oxygen bonded to phosphorus.
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Category 5 based on SPECIES: Rat; ENDPOINT: LD50; VALUE:2719mg/kg; REFERENCE SOURCE: ACGIH (2001), PDS No.8 (1978)
1	Acute toxicity （Dermal）	Category 4		Warning	H312: Harmful in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	It was set as Category 4 based on LD50 = 1082mg/kg calculated from four data (PATTY (5th, 2001), PDS No.8 (1978)) of rabbit LD50 values.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	There is only data LC50 >1.3mg/L in the study considered to be based on a dust. So it cannot be classified.
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	It was set as Category 3 based on the statement that mild irritation was seen in the animal (PATTY (5th, 2001), RTECS (2004)), and the statement that there was irritant by contact in humans (HSFS (2000)).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on the statement that there is slight irritation in animals, it was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Not classified	-	-	-	-	We classified it as Out Of Category based on the statement that it had no skin sensitization property for the animals(PATTY (5th, 2001)).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Not classified	-	-	-	-	It was considered as the outside of category based on the description that the effect is not observed on fertility property of parents and generating and growth of a child at the dose causing general toxicity to parents (ACGIH (2001), PDS No.8 (1978)).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	There is a statement (ACGIH (2001), PATTY (5th, 2001)) that a organophosphate poisonings specific symptoms and cholinesterase inhibition are acknowledged by oral administration at the dosage of the guidance value range of Category 2 with rats and mice. In humans, there is a statement (HSDB (2005), SITTIG (47th, 2002)) that the symptoms of severe poisoning is developed by inhalations and contacts, and that headache, perspiration, nausea, vomiting, diarrhea, coordinated movement loss, and death are seen by contact. It was set as Category 2 (nerve systems) based on the above information.
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	There is a statement that red blood cell cholinesterase inhibition in rats, mice, and dogs exposed to guidance value within the limits of Category 1is observed, and that typical cholinergic organophosphate intoxication is observed in those exposed to guidance value within the limits of Category 2 (ACGIH (2001), PATTY (5th, 2001), PDS No.8 (1978)). In humans, it is stated that respiratory insufficiency, debility, and prick pain feeling and incoodination at arms and legs are observed, and that the effect of the cholinesterase inhibitor may be accumulated (HSFS (2000), SITTIG (47th, 2002)). It was classified into Category 1 (nerve systems) based on the above information.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	Insufficient data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	Classification not possible due to lack of data

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）