GHS Classification Result

Chemical Name:Demeton (mixed isomers)
CAS:8065-48-3

Result:
ID: 828
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Category 3 because of its flash point: 45degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-reactive properties present.
9 Pyrophoric liquids Not classified - - - - Flash point: 464degC (ICSC, 2002; Weiss (2nd, 1985)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Based on that aqueous solubility is measured (ICSC (2002), SRC (2005), HSDB (2005)), it is judged that it is stable in the water.
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to phosphorus.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Mixture: Category 1, O-: Category 1, S-: Category 1 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Mixture: It was set as Category 1 based on LD50= 2.5mg/kg calculated from six date of rat LD50 value (ACGIH (2002), DFGOT vol.9 (2003), PATTY (5th, 2001) vol.7, PDS (1987)). O-object: It was set as Category 1 based on LD50= 1.5mg/kg calculated from four data of rat LD50 values (ACGIH (2002), DFGOT vol.9 (2003), PATTY (5th, 2001)). S-object: It was set as Category 1 based on LD50= 1.5mg/kg calculated froom five data of rat LD50 value (ACGIH (2002), DFGOT vol.9 (2003), PATTY (5th, 2001)).
1 Acute toxicity (Dermal) Mixture: Category 1, O-: Classification not possible, S-: Classification not possible Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Mixture: It was set as Category 1 based on rat LD50= 8.2mg/kg (ACGIH (2002), DFGOT vol.9 (2003), PDS (1987)). O-body: no data. S-body: no data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Mixture: Classification not possible, O-: Classification not possible, S-: Classification not possible - - - - Mixture: no data available; O-, S-: no data available
1 Acute toxicity (Inhalation: Dusts and mists) Mixture: Category 1, O-: Classification not possible, S-: Classification not possible Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since the this vapor saturated vapor pressure of the mixture: material is 0.297ppm (0.003mg/L), it is thought that the inhalation study was done in mist. It was set as Category 1 based on LC50 = 0.0439mg/L calculated from four data (ACGIH (2002), PATTY (5th, 2001)) of rat LC50 value. O-body: datum without. S-body: datum without.
2 Skin corrosion/irritation Mixture: Classification not possible, O-: Classification not possible, S-: Classification not possible - - - - Mixture: no data. O-body: no data. S-body: no data.
3 Serious eye damage/eye irritation Mixture: Category 2A-2B, O-: Classification not possible, S-: Classification not possible Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Mixtures: Based on the statement (HSDB (2005) that in humans redness, hurt in humans (ICSC (J), (2002), blurred visions and tearing are seen, it was set as Category 2A-2B. O-body: No data S-body: No data
4 Respiratory sensitization Classification not possible (Mixture, O-, S-) - - - - Mixture:No data. O-: No data. S-: No data.
4 Skin sensitization Classification not possible (Mixture, O-, S-) - - - - Mixture:No data. O-: No data. S-: No data.
5 Germ cell mutagenicity Mixture: Category 2, O-: Not classified, S-: Classification not possible Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Compound : Since there are no results of human generation epidemiology, generation mutagenicity test, or productive cell in vivo mutagenicity test result. There is a positive result of the somatic cell in vivo mutagenicity test (chromosome aberration test on hamster bone marrow cells) indicated in DFGOT vol.9 (2003), and there besis no positive finding with the productive cell in vivo genotoxicity study. So it was classified as Category 2. O-body : Since there is no humans generation epidemiological information; negative result of generation mutagenicity tests (dominant lethal test on mouse) is indicated in DFGOT vol.9 (2003), and there is no positive result with the productive cell and the somatic cell in vivo mutagenicity test. So it was classified as out of Category. S-body: No data.
6 Carcinogenicity Mixture: Classification not possible, O-: Classification not possible, S-: Classification not possible - - - - Mixture: no data. O-object: no data. S-object: no data.
7 Reproductive toxicity Mixture: Category 2, O-: Classification not possible, S-: Classification not possible Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Mixture : It was classified into Category 2 because that fetotoxicity (reduction of fetal weight, the increase in mortality rate, etc.) is observed, although it is small, skeletal abnormalities are also observed, but there is no description on general toxicity in parent animals in the rat and mouse administration examination of the abdominal cavity (DFGOT vol.9 (2003), PATTY(5th, 2001) vol.7, PDS (1987)). O-object: no data. S-object: no data.
8 Specific target organ toxicity - Single exposure Mixture: Category 1(nervous system), O-: Classification not possible, S-: Classification not possible Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Mixture; It was set as Category 1 (nerve systems) based on the statement (DFGOT vol. 9(2003), PATTY (5th, 2001) vol.7, PDS (1987), ICSC (J) (2002), and HSDB (2005)) that significant reduction of plasma cholinesterase activity was acknowledged in terms of mixture for humans by the dosage of guidance value within the limits of Category 1, and that twitch, dizziness, closeness, feeling of sickness, vomited, miosis, muscle spasticity, the salivatsweating, and unconsciousness were seen by inhalation, and stomach cramps, diarrhea and vomiting were seen by intakes. O-body; There is no data. S-body; There is no data.
9 Specific target organ toxicity - Repeated exposure Mixture: Category 1(nervous system), O-: Classification not possible, S-: Classification not possible Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Mixture: in rats, dogs, rabbits and guinea pigs, at the dosage of the guidance value range of Category 1, it is stated that inhibition of the cholinesterase activity inside of blood and in brain is observed, and toxic symptoms such as muscle fasciculation, debility, tremor, lacrimation, the salivation, dyspnea, nasal and mouth bubble, diarrhea, muscle paralysis, coma, and mild asphyxial convulsions were observed (ACGIH (2002), DFGOT vol.9 (2003), PDS (1987)). In humans, there is a statement that shows inhibition of plasma cholinesterase activity was observed (ACGIH (2002), DFGOT vol.9 (2003), PATTY(5th, 2001) vol.7). It was classified into Category 1 (nerve systems) based on these information. O-object: data not available. S-object: data not available.
10 Aspiration hazard Mixture: Classification not possible, O-: Classification not possible, S-: Classification not possible - - - - Mixture: no data available; o- and s-: no data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50=14.0microg/L of Crustacea (Water flea), and others (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, rapid degradability is unknown, though supposed less bioaccumulative (log Kow=3.21 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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