GHS Classification Result

Chemical Name：Iron trichloride
CAS：7705-08-0

Result：
ID: 831
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ISCS (2004))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ISCS, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although contact with waters hydrolyzes, product is ferric hydroxides of nonflammables and hydrochloric acids. So it is not a combustible.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Not classified in UNTDG Class: 5.1
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - The test suitable for a solids material is not established. (There is a statement that it exerts corrosive effects on a great portion of metal (Hommmel (1991)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was classified into Category 4 from the statistics calculated value of rat LD50 value (316 mg/kg).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category1C from their being those with written that solid caused a burned to humans (HSDB (2005)), and UN classification classes 8 III. .
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		There is the statement as causing a burned in humans, and skin corrosivity/irritation is Category1C, it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - There is no data and we could not classify it.
4 Skin sensitization Classification not possible - - - - The data is insufficient, because in the test using two guinea pigs, first one gave a positive result and the second one gave negative. Although there are two reports about humans, we could not classify them, since these were singular report in the workplaces handling much other metals and we could not determine that it was affected by the ferric chloride.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is a statement that as for in vivo examinations, it was negative in chromosome aberration test on mouse testis, positive in mouse micronucleus examination, and positive in chromosomal aberration test of mouse bone marrow cell (IUCLID (2000)), and there is no positive result reported for productive cell in vivo genotoxicity studies. So it was classified as Category 2. The result of in vitro test (Ames test) was negative.
6 Carcinogenicity Not classified - - - - It was considered as the outside of Category based on the description that in the test of drinking water and baiting medication of a rat, it was all negative (HSDB (2005)) (IUCLID (2000)).
7 Reproductive toxicity Classification not possible - - - - It was not teratogenecity and fetotoxicity in mouse administration in drinking water,(IUCLID (2000)). Moreover, it affects sperm morphology taked from the epididymidis of rats in abdominal administration. There is a statement that sperm motility is reducted and reactive oxygen species competence of cauda epididymidis is reducted in mouse 14-days feeding administration test (HSDB (2005)). However, it cannot be classified due to insufficiency of data.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (systemic toxicity)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In humans, it was set into Category 3 (respiratory irritant) according to the statement that respiratory tracts are stimulated through dust and mists (ACGIH (2001)). There is a statement of the abnormalities of consciousness disorder, tachycardia, tachypnea, lasting nausea, acid hemie, and blood biochemistry by accidental ingestions (HSDB (2005)), and it was set into Category 2 (systemic toxicity) from it being priority 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Without reports on humans slight impact was seen with value of Category 2 out of the guidance only in animal experiments; due to insufficient data, it cannot be classified.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 1 because of "aspiration pneumonia" (HSDB, 2005)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=9600microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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