GHS Classification Result

Chemical Name:Disulfiram
CAS:97-77-8

Result:
ID: 833
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable" (ICSC (J) (2002))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on Rat LD50 values: 8600mg/kg (ACGIH 7th, 2001, NTP TR 166, 1979), 1300mg/kg, 2500mg/kg, and 3100mg/kg (DFGOT vol.5, 1993). Since the calculated value was 2244mg/kg, it was set as Category 5.
1 Acute toxicity (Dermal) Not classified - - - - Based on rabbit LD50 value: >2000mg/kg (IUCLID, 2000, HSDB, 2006), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - In the test applied to the skin of the rabbit of DFGOT (vol.5, 1993), slight erythema was admitted, but it disappeared 6 hours afterward. Acceptance criteria of irritation was not suited and it was carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description that mild irritation was acknowledged in the test applied to the eye of the rabbit (IUCLID (2000)), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although it is classified to be Sh (MAK/BAT, 2004) according to DFG, there was no evidence which suggests that skin contacts induce hypersensitivity in humans, therefore it was presupposed that we cannot classify it because of the insufficiency of the data.
5 Germ cell mutagenicity Classification not possible - - - - Since there is a negative result with the micronucleus test, an in vivo mutagenicity test with somatic cell on mouse marrow cells (IUCLID, 2000), it is considered to be out of Category. However, there is only data of in vitro examination with the source of Priority 1, and it could not negate toxicity clearly. So it was presupposed that it cannot be classified due to data insufficiency.
6 Carcinogenicity Not classified - - - - It was classified into a group 3 (IARC Suppl.7 1987) in IARC and was classified into A4 (ACGIH 7th, 2001) in ACGIH. So it was considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a description that malformations (two cases) or abortion (one case) was observed in five pregnant women exposed in early pregnancy (DFGOT (vol. 5, 1993)). In addition, there is a description that functional disorders of female genitalia are caused by occupational exposure. However, since it was not a sufficient evidence to be considered as Category 1A, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
In DFGOT (vol.5, 1993), from description that as for the children ingested large amount orally was acknowleged pupillary dilation, uneasy and depression, and headaches and locomotor ataxias were acknowledged to adults. It judged that a nervous systems was affected and was set as Category 1 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver, thyroid, endocrine system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, thyroid, endocrine system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on descriptions that a polyneuropathy and etc. are acknowledged as side effects at the time of taking in as a drug of ACGIH (7th, 2001), that In the example of long-term oral ingestion of DFGOT (vol.5, 1993), mood disorders, liver damage and change of the hormone concentration in blood etc. were acknowledged, and that hyperplasia of the thyroid gland accompanied by iodine uptake decreases was observed with the given dose of the guidance value range of Category 1 in the oral study using the rat of DFGOT (vol.5, 1993), it was classified into Category 1 (nervous systems, liver, the thyroid gland, endocrine system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour LC50=120microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, and supposed not rapidly degrading (estimated by the decomposition rate of tetraethylthiuram disulfide by BOD: 2.8% (Existing Chemicals Safety Check Data)), though supposed less bioaccumulative (log Kow=3.88 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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