GHS Classification Result

Chemical Name:(N-(1,1,2,2-Tetrachloroethylthio)-1,2,3,6-tetrahydrophthalimide); Captafol
CAS:2425-06-1

Result:
ID: 835
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not ignite spontaneously on coming into contact with air at normal temperatures
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. From description that rat LD50 values: 2500 to 6200 mg/kg (JMPR (1969), PIM 097 (1990), IARC 53 (1991)), 5000mg/kg (JMPR, 1969), and 2500 to 6200 mg/kg (AI exchange: 2000 to 4960 mg/kg) about 80% Wettable Powder, statistics calculation was done. It was set as Category 5 based on the calculated value 3067mg/kg.
1 Acute toxicity (Dermal) Not classified - - - - Based on the description that >15400mg/kg (AI reduced value: >12321mg/kg) about rabbit LD50 value: 15400mg/kg (IARC 53 (1991)) and 80% Wettable powder), it was set as the outside of Category
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It was set as Category 2 by description that there was moderate irritation to the skin of the rabbit (ACGIH (7th, 2001)), and by description that many stimulative and allergic examples of contact dermatitis development of symptoms were reported in the agriculture and forestry pursuers of handling KYAPUTAFORU in Kumamoto, other domestic areas, and New Zealand (PIM 097 (1990), ACGIH (7th, 2001)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
There is the description that in the test applied to the eye of the rabbit, corneal opacities, irritation responses to iris and conjunctival continued 21 days after the application (PIM(2005)), and the description that there is a report in humans occupational exposure causes conjunctivitis and eyelid edema (PIM 097 (1990). Based on these description (in the ACGIH (7th, 2001)), it was set as Category 2A.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
It was classified as Category 1 based on the description of PATTY (4th, 1994) and ACGIH (7th, 2001) that "Captafol has skin sensitizing effect and respiratory sensitization effect in human."
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was categorized as Category 1 based on the descriptions in PIM 097 (1990), IARC 53 (1991), PATTY (4th, 1994) and ACGIH (7th, 2001) that many cutaneous sensitization properties and optical allergic reactions were acknowledged in the farmers of Japan, silviculture workers of New Zealand, and the researchers of the chemistry maker laboratories, and the descriptions of PATTY (4th, 1994) and ACGIH (7th, 2001) that "Captafol has cutaneous sensitizing property and respiratory sensitizing property in human."
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although the result of dominant lethal test on mouse, an in vivo generation mutagenicity test on germ cells, was negative (JMPR (1997) and IARC 53 (1991)), the results of the dominant lethal test on rats, both IP injection and oral administration, were weak positivities (IARC 53 (1991)). So it was classified as Category 1B. In addition, it is positive in the test systems which does not include metabolic activation system in the chromosomal aberration test and micronucleus test which are in vitro mutagenicity test using somatic cells (IARC 53 (1991)).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into A4 in ACGIH (7th, 2001), but it was classified into 2A in IARC 53 (1991) and was classified into the category 2 in EU (an evaluation year was unknown). So it was considered as Category 1B, prioritizing evaluation of IARC.
7 Reproductive toxicity Not classified - - - - Since malformation and toxicity was not observed of fetuse in rat teratogenicity test with the dose affecting maternal, and only the minimum effect was observed in the fetal in the rat two-generation reproduction study at the dose affecting maternal, it was considered as the outside of Category.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, urinary bladder), Category 2 (liver) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (kidney, urinary bladder)
H373: May cause damage to organs through prolonged or repeated exposure (liver)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on descriptions that in study of dogs, it was observed that degeneration of the transitional-epithelium cell of the kidney and the bladder with the oral dosage of the guidance value range of Category 1 in the 12-month (IRIS, 1987 evaluation), and that in the chronic toxicity study of a rat it was observed that organization injury, such as degeneration of hepatocytes of liver and renal tubules at the dosage of the guidance value range of Category 2 in the feeding administration during two years (JMPR, 1977;IRIS, and 1987, and PATTY, 4th, and 1994), it was classified into Category 1 (the kidney, bladder) and Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=20.6microg/L of fishes (Rainbow trout) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.8(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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